Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Apr 15, 2026; 18(4): 115687
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115687
Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115687
Clinical prediction of carcinoembryonic antigen combined with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for postoperative survival in colorectal cancer
Tao Wang, Department of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Chang Liu, Research and Development Center, Autobio Diagnostics Co., Ltd, Zhengzhou 450000, Henan Province, China
Jun Jiang, Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Co-first authors: Tao Wang and Chang Liu.
Author contributions: Wang T and Liu C contributed equally as co-first authors; Wang T, Liu C, and Jiang J contributed to research design and data analysis; Wang T contributed to data collection and paper writing; Liu C and Jiang J contributed to reviewing and editing; Jiang J was responsible for funding application, communication coordination, ethical review, copyright and licensing, and follow-up; all authors have read and approve the final manuscript.
Institutional review board statement: The research was reviewed and approved by the Ethic Committee of The First Affiliated Hospital of Hebei North University.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The raw and processed data supporting the conclusions of this study are available from the corresponding author upon reasonable request.
Corresponding author: Jun Jiang, PhD, Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. jiangjunpub@126.com
Received: November 4, 2025
Revised: December 11, 2025
Accepted: January 19, 2026
Published online: April 15, 2026
Processing time: 154 Days and 23 Hours
Revised: December 11, 2025
Accepted: January 19, 2026
Published online: April 15, 2026
Processing time: 154 Days and 23 Hours
Core Tip
Core Tip: This study investigated the predictive value of the inflammatory markers neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio combined with the tumor marker carcinoembryonic antigen for postoperative survival in patients with colorectal cancer. The results showed that the combined detection of the three markers demonstrated significantly superior predictive efficacy compared to any single indicator, providing an efficient and convenient clinical tool for assessing the prognosis of colorectal cancer patients.