Bidirectional relationship between depression and the risk and prognosis of gastric cancer

doi:10.4251/wjgo.v17.i12.113272

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Dec 15, 2025; 17(12): 113272
Published online Dec 15, 2025. doi: 10.4251/wjgo.v17.i12.113272

Bidirectional relationship between depression and the risk and prognosis of gastric cancer

Zhe Chen, Ting-Jie Gong, Lu Zhao

Zhe Chen, Ting-Jie Gong, Lu Zhao, Department of Oncology, Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Wuxi 214000, Jiangsu Province, China

Co-first authors: Zhe Chen and Ting-Jie Gong.

Author contributions: Chen Z and Gong TJ jointly participated in study design, data collection, and manuscript drafting as co-first authors; Zhao L served as the corresponding author, overseeing the overall research process, coordinating author collaborations, addressing peer review comments, and ensuring the integrity and finalization of the manuscript. All authors have read and approved the final version.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Lu Zhao, Department of Oncology, Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, No. 8 Zhongnan West Road, Binhu District, Wuxi 214000, Jiangsu Province, China. lorraine0318@163.com

Received: August 26, 2025
Revised: September 26, 2025
Accepted: November 7, 2025
Published online: December 15, 2025
Processing time: 107 Days and 0.4 Hours

Core Tip

Core Tip: This minireview reveals a bidirectional relationship between depression and gastric cancer. Depression activates the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, promoting tumor progression through pathways such as the β2-adrenergic receptor. Conversely, gastric cancer induces depression through psychosocial and pathophysiological mechanisms. This vicious cycle provides a theoretical basis for clinical interventions designed to improve patient outcomes and quality of life.