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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2025; 17(11): 110798
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.110798
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.110798
Evaluation of pancreatic adenocarcinoma with tumor budding and lymphocytic infiltration as prognostic marker
Sunil V Jagtap, Department of Pathology, Krishna Vishwa Vidyapeeth, Krishna Institute of Medical Sciences, Karad 415110, Maharashtra, India
Shubham S Jagtap, Department of Medicine, Krishna Vishwa Vidyapeeth, Krishna Institute of Medical Sciences, Karad 415110, Maharashtra, India
Co-first authors: Sunil V Jagtap and Shubham S Jagtap.
Author contributions: Jagtap SV designed the research study and contributed new update and analytic tools; Jagtap SS analyzed the data, have read and approved the final manuscript; Jagtap SV and Jagtap SS performed the research and wrote the manuscript; Jagtap SV and Jagtap SS contributed equally to this manuscript and are co-first authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sunil V Jagtap, MD, Professor, Department of Pathology, Krishna Vishwa Vidyapeeth, Krishna Institute of Medical Sciences, Malkapur, Karad 415110, Maha
Received: June 16, 2025
Revised: July 18, 2025
Accepted: September 8, 2025
Published online: November 15, 2025
Processing time: 151 Days and 19.2 Hours
Revised: July 18, 2025
Accepted: September 8, 2025
Published online: November 15, 2025
Processing time: 151 Days and 19.2 Hours
Core Tip
Core Tip: Pancreatic ductal adenocarcinoma is highly invasive pancreatic neoplasm, having globally 495773 new cases and 466003 new deaths reported in 2020. This article is to evaluate the prognostic importance of tumor budding (TB) and tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma and its correlation as prognostic marker. A high TB was a poor prognostic feature and might be a target for tumor-specific treatments. While high T-cell infiltration, especially of CD8+ T cells is linked to better outcomes. Future, TB and tumor lymphocytic infiltration should be taken into consideration and included in pathology reports. This knowledge is crucial for clinicians to better assess patient prognosis.