Saito M, Kanaya M, Miyashita N, Yokoyama E, Izumiyama K, Mori A, Morioka M, Kondo T. Colorectal follicular lymphoma: A single-center retrospective study. World J Gastrointest Oncol 2025; 17(10): 110302 [PMID: 41114104 DOI: 10.4251/wjgo.v17.i10.110302]
Corresponding Author of This Article
Makoto Saito, Chief Physician, Blood Disorders Center, Aiiku Hospital, Chuo-ku Minami 4 Nishi 25, Sapporo 064-0804, Hokkaido, Japan. ikyoku@aiiku-hp.or.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 15, 2025 (publication date) through Oct 26, 2025
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Journal Information of This Article
Publication Name
World Journal of Gastrointestinal Oncology
ISSN
1948-5204
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Saito M, Kanaya M, Miyashita N, Yokoyama E, Izumiyama K, Mori A, Morioka M, Kondo T. Colorectal follicular lymphoma: A single-center retrospective study. World J Gastrointest Oncol 2025; 17(10): 110302 [PMID: 41114104 DOI: 10.4251/wjgo.v17.i10.110302]
Makoto Saito, Minoru Kanaya, Naoki Miyashita, Emi Yokoyama, Koh Izumiyama, Akio Mori, Masanobu Morioka, Takeshi Kondo, Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan
Author contributions: Saito M designed this study and wrote the manuscript; Saito M, Kanaya M, Miyashita N, Yokoyama E, Izumiyama K, Mori A, Morioka M, Kondo T made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; All authors gave final approval of the version to be published and agree to be accountable for all aspects of the work.
Institutional review board statement: This study was conducted in accordance with the World Medical Association Declaration of Helsinki, and was approved by the Aiiku Hospital Clinical Research Review Board (No. 202505201).
Informed consent statement: All 5 patients provided written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: June 4, 2025 Revised: June 11, 2025 Accepted: August 28, 2025 Published online: October 15, 2025 Processing time: 132 Days and 21.4 Hours
Abstract
BACKGROUND
The concept of “duodenal-type follicular lymphoma (FL)” has already been established as a disease entity. On the other hand, because FL that develops in the colorectum is a rare disease, its clinical characteristics, including its treatment and outcome, are poorly understood.
AIM
To clarify the characteristic clinical features of colorectal FL.
METHODS
We identified 5 patients with FL from December 2010 to July 2022 whose colorectal lesions were confirmed by endoscopic biopsy at our hospital and retrospectively examined their clinical features, including endoscopic findings, treatment, and long-term outcomes.
RESULTS
The median age of the patients was 70 years (range 62-74 years, 3 males and 2 females), and 2 patients were considered to have systemic FL lesions. Endoscopic findings revealed elavated lesions in all 5 patients (polypoid 3, flat elavated 1, papular 1). Only 1 patient underwent therapeutic intervention, and 4 patients chose watchful waiting. Except for 1 patient in which the lesion spontaneously regressed, the disease recurred or progressed in 4 patients, 3 of whom eventually achieved near complete remission with the administration of rituximab and bendamustine (± polatuzumab vedotin). The 5 patients in this study were still alive or exhibited long-term survival before death; the survival time ranged from 8-29 years after the onset of lymphoma.
CONCLUSION
In the present study, colorectal FL progressed slowly, and overall survival was good because it was sensitive to anticancer drugs even after the disease progressed without initial therapeutic intervention.
Core Tip: Follicular lymphoma (FL) occurring in the duodenum has already been established as a disease concept within the category of FL. In response to this, clinical characteristics of the colorectal FL, including its treatment and long-term outcome, are poorly understood owing to the rarity. This study aimed to clarify the characteristic clinical features of the colorectal FL. In the present study, colorectal FL progresses indolently, as with cases of nodal or duodenal lesions, and the overall survival was good because it was sensitive to chemotherapy with administration of bendamustine and rituximab even after the disease progressed without initial treatment.
