Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging

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Sep 26, 2025 (publication date) through Sep 24, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2025; 17(9): 108049
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.108049

Table 1 Safety evaluation of umbilical cord-derived mesenchymal stem cell-conditioned medium

Toxicity	Test	Target	Result
Toxicity for skin	Skin irritation test	Rabbit	Pass
	Eye irritation test	Rabbit	Pass
	Skin sensitization test	Guinea pig	Pass
	Photosensitization test	Guinea pig	Pass
	Phototoxicity test	Guinea pig	Pass
	Single dose toxicity	Rat	Pass
	Repeated dose toxicity	Rat	Pass
Genotoxicity	Micronucleus test	Mouse	Pass
	Bacterial reverse mutation test	Escherichia coli (WP2 uvrA), Salmonella typhimurium (TA98, TA100, TA1535, and TA1537)	Pass
	Chromosomal abnormality test	Chinese hamster lung cell	Pass

Citation: Ahn H, Han HS, Lee KH. Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging. World J Stem Cells 2025; 17(9): 108049
URL: https://www.wjgnet.com/1948-0210/full/v17/i9/108049.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i9.108049