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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2025; 17(9): 108049
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.108049
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.108049
Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging
Hyunjun Ahn, Kye-Ho Lee, Stem Cell Treatment and Research Institute, Bio-Beauty & Health Company, Seoul 04420, South Korea
Ho-Seong Han, Department of Surgery, Seoul National University Bundang Hospital, College of Medicine, Seoul National University, Seongnam-si 13620, Gyeonggi-do, South Korea
Author contributions: Ahn H, Han HS, and Lee KH contributed to the conceptualization and writing - review & editing; Han HS and Lee KH participated in the project administration; Ahn H contributed to the data curation, formal analysis, investigation, methodology, visualization, and writing - original draft preparation; Lee KH contributed to funding acquisition, resources, and supervision.
Institutional animal care and use committee statement: All animal experiments were performed in accordance with the National Institute of Health Guidelines for the Care and Use of Laboratory Animals and the Seoul National University Bundang Hospital Institutional Animal Care and Use Committee in Bundang, South Korea (BA-2207-347-001-01).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding or first author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kye-Ho Lee, PhD, Stem Cell Treatment and Research Institute, Bio-Beauty & Health Company, No. 72 UN Village Gil, Yongsan-gu, Seoul 04420, South Korea.
Received: April 10, 2025
Revised: June 12, 2025
Accepted: August 29, 2025
Published online: September 26, 2025
Processing time: 167 Days and 21.7 Hours
Revised: June 12, 2025
Accepted: August 29, 2025
Published online: September 26, 2025
Processing time: 167 Days and 21.7 Hours
Core Tip
Core Tip: Umbilical cord-derived mesenchymal stem cell-conditioned medium (UCMSC-CM) contains higher levels of effective factors than adipose-derived mesenchymal stem cell-conditioned medium, enhancing skin fibroblast proliferation and inhibiting melanin production in vitro. It promotes skin regeneration more effectively than adipose-derived mesenchymal stem cell-conditioned medium in aged skin in vivo. Subcutaneous injection of UCMSC-CM was the most effective method for promoting skin regeneration in aged skin in vivo. A non-clinical safety evaluation indicated that UCMSC-CM is a safe substance. These findings highlight UCMSC-CM as a promising and effective treatment for skin aging.