©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2015; 7(8): 1109-1117
Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1109
Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1109
From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases
Antonin Bukovsky, The Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic
Author contributions: The manuscript has been solely written by Bukovsky A.
Conflict-of-interest statement: Author submitted the Provisional Patent Application LNG FILE NO. 71169.PV3 dated Feb., 2, 2015, entitled “Novel Methods of Treating Ovarian Infertility in Older and POF Women, Testicular Infertility, and Other Human Functional Diseases”.
Correspondence to: Antonin Bukovsky, MD, PhD, DSc, Professor, The Institute of Biotechnology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 14220, Czech Republic. a_buko@comcast.net
Telephone: +420-865-9640081
Received: September 4, 2014
Peer-review started: September 5, 2014
First decision: December 23, 2014
Revised: August 1, 2015
Accepted: August 13, 2015
Article in press: August 14, 2015
Published online: September 26, 2015
Processing time: 386 Days and 2.8 Hours
Peer-review started: September 5, 2014
First decision: December 23, 2014
Revised: August 1, 2015
Accepted: August 13, 2015
Article in press: August 14, 2015
Published online: September 26, 2015
Processing time: 386 Days and 2.8 Hours
Core Tip
Core tip: Sex steroid combinations have been found to transdifferentiate in vitro the vascular smooth muscle cells into neurons. Therefore, utilization of sex steroid combinations may enable regeneration of neural tissues affected by acute/traumatic disorders. In aging individuals, however, an altered immune system components in the stem cell niche may be unable to preserve regenerating cells in the functional stage due to the immune system regression with age advancement. This could be improved by transfer of blood mononuclear cells from young healthy individuals. Beside that, the local and systemic utilization of honey bee propolis alone has been found to ameliorate some age-induced disorders.