Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?

doi:10.4252/wjsc.v7.i2.408

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Mar 26, 2015 (publication date) through Mar 9, 2026

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Mar 26, 2015; 7(2): 408-417
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.408

Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?

Martha L Arango-Rodriguez, Fernando Ezquer, Marcelo Ezquer, Paulette Conget

Martha L Arango-Rodriguez, Fernando Ezquer, Marcelo Ezquer, Paulette Conget, Center for Regenerative Medicine, School of Medicine Clínica Alemana Universidad del Desarrollo, Santiago 7710162, Chile

Author contributions: Arango-Rodriguez ML, Ezquer F, Ezquer M and Conget P contributed to this paper.

Supported by FONDECYT to Paulette Conget, No. 1130760.

Correspondence to: Paulette Conget, PhD, Center for Regenerative Medicine, School of Medicine Clínica Alemana Universidad del Desarrollo, Av. Las Condes 12438, Lo Barnechea, Santiago 7710162, Chile. pconget@udd.cl

Telephone: +56-2-23279302 Fax: +56-2-23279306

Received: July 12, 2014
Peer-review started: July 12, 2014
First decision: September 24, 2014
Revised: October 1, 2014
Accepted: November 7, 2014
Article in press: November 10, 2014
Published online: March 26, 2015
Processing time: 251 Days and 10.1 Hours

Core Tip

Core tip: Mesenchymal stem cells (MSCs) derived from different origins have recently received much attention as potential therapeutic. However, such cells also appear to have essential functions in building and supporting tumor microenvironments. Here, we review the effect of MSCs on tumor establishment, as also susceptibility to infection and its progression. The literature reveals incongruity regarding the impact of MSCs on the development of cancer and infection; such paradoxical effect might be attributed to differences in isolation and expansion conditions, the source and dose of the cells, the administration route and its timing and host characteristics. MSCs immunomodulatory potential seems to be the leading mechanism responsible for such effects.