Letter to the Editor: Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration

doi:10.4252/wjsc.v18.i4.115733

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World Journal of Stem Cells

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Apr 26, 2026; 18(4): 115733
Published online Apr 26, 2026. doi: 10.4252/wjsc.v18.i4.115733

Letter to the Editor: Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration

Sasi Nivruthi, Dilipkumar Preetha, Nagarajan Selvamurugan

Sasi Nivruthi, Dilipkumar Preetha, Nagarajan Selvamurugan, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India

Author contributions: Nivruthi S and Preetha D wrote the manuscript; Selvamurugan N revised the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in

Received: October 24, 2025
Revised: November 30, 2025
Accepted: January 14, 2026
Published online: April 26, 2026
Processing time: 179 Days and 2.5 Hours

Core Tip

Core Tip: A review by Cong et al highlighted stem cell-driven cartilage regeneration. Stem cell-based strategies redefine cartilage repair by integrating the regenerative potential of stem cells with tissue-engineering innovations. However, a thorough understanding of the therapeutic potential of these strategies requires consideration of several key aspects. First, careful regulation of progenitor cell differentiation is essential to promote stable chondrocyte formation while preventing hypertrophy. Second, a thorough analysis of clinical studies is required to assess sample sizes and therapeutic efficacy compared with placebo controls. Third, the chondrocyte microenvironment that hosts the bioengineered materials must be addressed.