Nivruthi S, Preetha D, Selvamurugan N. Letter to the Editor: Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration. World J Stem Cells 2026; 18(4): 115733 [DOI: 10.4252/wjsc.v18.i4.115733]
Corresponding Author of This Article
Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in
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Cell & Tissue Engineering
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Apr 26, 2026 (publication date) through Apr 22, 2026
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World Journal of Stem Cells
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1948-0210
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Nivruthi S, Preetha D, Selvamurugan N. Letter to the Editor: Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration. World J Stem Cells 2026; 18(4): 115733 [DOI: 10.4252/wjsc.v18.i4.115733]
World J Stem Cells. Apr 26, 2026; 18(4): 115733 Published online Apr 26, 2026. doi: 10.4252/wjsc.v18.i4.115733
Letter to the Editor: Advances in bioengineering and translational progress of stem cell-driven cartilage regeneration
Sasi Nivruthi, Dilipkumar Preetha, Nagarajan Selvamurugan
Sasi Nivruthi, Dilipkumar Preetha, Nagarajan Selvamurugan, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India
Author contributions: Nivruthi S and Preetha D wrote the manuscript; Selvamurugan N revised the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Nagarajan Selvamurugan, PhD, Professor, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nādu, India. selvamun@srmist.edu.in
Received: October 24, 2025 Revised: November 30, 2025 Accepted: January 14, 2026 Published online: April 26, 2026 Processing time: 179 Days and 2.5 Hours
Abstract
Trauma to the articular cartilage leads to movement restriction. As the articular cartilage has a definitive regeneration capacity owing to its avascular and aneural nature, several therapeutic approaches have been explored. Cong et al elaborated on the strategies and innovations in stem cell-based cartilage regeneration. Its systematic organization - advancing from cartilage structure to stem cell sources, engineering methodologies, preclinical studies, clinical applications, and future prospects - offers researchers a coherent framework for understanding this intricate domain. This review highlights current limitations in cartilage repair, engineering innovations, and major preclinical and clinical trials employing stem cell-centered approaches. Despite its comprehensive coverage, this review does not provide an in-depth focus on certain techniques discussed in this article.
Core Tip: A review by Cong et al highlighted stem cell-driven cartilage regeneration. Stem cell-based strategies redefine cartilage repair by integrating the regenerative potential of stem cells with tissue-engineering innovations. However, a thorough understanding of the therapeutic potential of these strategies requires consideration of several key aspects. First, careful regulation of progenitor cell differentiation is essential to promote stable chondrocyte formation while preventing hypertrophy. Second, a thorough analysis of clinical studies is required to assess sample sizes and therapeutic efficacy compared with placebo controls. Third, the chondrocyte microenvironment that hosts the bioengineered materials must be addressed.
