Jameel F, Sahibdad I, Muhammad SG, Salim A. Wound pathophysiology and healing dynamics for stem cell-mediated therapeutics in different skin wounds. World J Stem Cells 2026; 18(3): 115658 [DOI: 10.4252/wjsc.v18.i3.115658]
Corresponding Author of This Article
Asmat Salim, Stem Cell Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Main University Road, Karachi 75270, Sindh, Pakistan. asmat.salim@iccs.edu
Research Domain of This Article
Research & Experimental Medicine
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 26, 2026 (publication date) through Mar 28, 2026
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Stem Cells
ISSN
1948-0210
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Jameel F, Sahibdad I, Muhammad SG, Salim A. Wound pathophysiology and healing dynamics for stem cell-mediated therapeutics in different skin wounds. World J Stem Cells 2026; 18(3): 115658 [DOI: 10.4252/wjsc.v18.i3.115658]
Fatima Jameel, Iqra Sahibdad, Sidra Ghulam Muhammad, Asmat Salim, Stem Cell Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Sindh, Pakistan
Author contributions: Jameel F developed the framework of the manuscript, contributed to the literature compilation, and drafted the initial content; Sahibdad I and Muhammad SG assisted with the comprehensive literature search and helped in manuscript writing; Salim A conceptualized the review topic, provided critical input, and finalized the content with significant revisions.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Asmat Salim, Stem Cell Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Main University Road, Karachi 75270, Sindh, Pakistan. asmat.salim@iccs.edu
Received: October 22, 2025 Revised: December 4, 2025 Accepted: February 3, 2026 Published online: March 26, 2026 Processing time: 154 Days and 15 Hours
Core Tip
Core Tip: Skin wound healing is a complex process affected by the type and severity of injury. This review provides a comparative overview of the pathophysiology of excisional, thermal, chemical, and cold-induced skin wounds while highlighting mesenchymal stem cell (MSC)-based regenerative strategies. It explains how MSCs modulate inflammation, promote angiogenesis, and support tissue remodeling through paracrine and immunomodulatory mechanisms. Additionally, it emphasizes optimizing MSC therapy via preconditioning (chemical, hypoxic, or genetic) and combining it with biomaterials like hydrogels and scaffolds to improve survival, engraftment, and functional recovery. The review also addresses translational barriers and the need for standardization in clinical applications, underscoring the potential of MSC-based treatments as future-oriented options for complex skin injuries.
