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World J Stem Cells. Feb 26, 2026; 18(2): 114433
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.114433
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.114433
Synergistic potential of combined neural stem cells and mesenchymal stem cells therapy in acute cerebral infarction: A perspective
Jing-Yu Li, Shu-Zhen Liu, Xin-Yi Xu, Lan Zhao, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Jing-Yu Li, Shu-Zhen Liu, Xin-Yi Xu, Lan Zhao, National Clinical Research Center for Chinese Medicine, Tianjin 300381, China
Co-first authors: Jing-Yu Li and Shu-Zhen Liu.
Author contributions: Li JY and Liu SZ contributed equally to this manuscript and are co-first authors. Li JY wrote the original draft; Liu SZ and Xu XY participated in drafting the manuscript; Zhao L participated in the supervision of this manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Lan Zhao, PhD, Professor, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. lanzhao69@163.com
Received: September 19, 2025
Revised: November 30, 2025
Accepted: January 12, 2026
Published online: February 26, 2026
Processing time: 148 Days and 20.5 Hours
Revised: November 30, 2025
Accepted: January 12, 2026
Published online: February 26, 2026
Processing time: 148 Days and 20.5 Hours
Core Tip
Core Tip: We note a recently published randomized controlled trial investigating the efficacy and mechanisms of combined mesenchymal and neural stem cell therapy for acute cerebral infarction. The study systematically validated, at the clinical level, the therapy’s role in promoting neurological recovery through the regulation of vascular endothelial growth factor and basic fibroblast growth factor, while demonstrating a favorable safety profile. In this letter, we share our perspectives.