©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Stem Cells. Feb 26, 2026; 18(2): 113930
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.113930
Published online Feb 26, 2026. doi: 10.4252/wjsc.v18.i2.113930
Synergetic pathways for Parkinson’s disease therapy: The intersection of exercise and stem cell science
An-Lin Zhang, The First Clinical College, Hainan Medical University, Haikou 571199, Hainan Province, China
Luan Wen, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hainan Medical University, Haikou 571199, Hainan Province, China
Luan Wen, Key Laboratory of Tropical Translational Medicine of Ministry of Education & Key Laboratory of Brain Science Research Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou 571199, Hainan Province, China
Author contributions: Zhang AL and Wen L wrote and approved the final version of the manuscript.
Supported by the National College Students’ Innovation and Entrepreneurship Training Program in Hainan Medical University, No. S202511810030.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Luan Wen, PhD, Professor, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hainan Medical University, No. 3 Xueyuan Road, Haikou 571199, Hainan Province, China. luanwen@muhn.edu.cn
Received: September 17, 2025
Revised: October 27, 2025
Accepted: January 12, 2026
Published online: February 26, 2026
Processing time: 150 Days and 5 Hours
Revised: October 27, 2025
Accepted: January 12, 2026
Published online: February 26, 2026
Processing time: 150 Days and 5 Hours
Core Tip
Core Tip: The most promising path forward for treating Parkinson’s disease may be through integrative therapies that synergistically combine regenerative medicine, such as stem cell transplants, with systemic interventions like exercise. This approach leverages exercise to prime the brain’s environment, thereby significantly enhancing the potential for cellular repair and urging a vital shift toward combined, interdisciplinary treatment strategies.