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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2026; 18(1): 115655
Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.115655
Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.115655
Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx
Ilya D Klabukov, Anastas Kisel, Elena Yatsenko, Denis S Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Kaluzhskaya Oblast’, Russia
Ilya D Klabukov, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Kaluzhskaya Oblast’, Russia
Yana Sulina, Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Moskva, Russia
Denis S Baranovskii, Institute of Systems Biology and Medicine, Russian University of Me
Author contributions: Klabukov ID designed and performed research, and wrote the manuscript; Kisel A, Sulina Y, and Baranovskii DS analyzed data; Yatsenko E revised the manuscript.
Supported by Russian Science Foundation, No. 24-64-00028.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ilya D Klabukov, PhD, Associate Professor, Head, Department of Rege
Received: October 22, 2025
Revised: November 1, 2025
Accepted: December 5, 2025
Published online: January 26, 2026
Processing time: 90 Days and 16.2 Hours
Revised: November 1, 2025
Accepted: December 5, 2025
Published online: January 26, 2026
Processing time: 90 Days and 16.2 Hours
Core Tip
Core Tip: Extracellular vesicles can promote or inhibit oncogenic progression by shaping the tumor microenvironment. The efficiency of extracellular vesicle delivery can be affected by the extracellular matrix and altered glycocalyx. The tumor extracellular matrix and cellular glycocalyx can create a permissive niche for invasion, immune evasion, and metastasis. These factors are also essential for predicting the effectiveness of targeted therapies and the responses of bystander cells. Understanding these factors is crucial for treating cancers that are resistant to immunotherapies.