Klabukov ID, Kisel A, Yatsenko E, Sulina Y, Baranovskii DS. Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx. World J Stem Cells 2026; 18(1): 115655 [DOI: 10.4252/wjsc.v18.i1.115655]
Corresponding Author of This Article
Ilya D Klabukov, PhD, Associate Professor, Head, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Kaluzhskaya Oblast’, Russia. ilya.klabukov@gmail.com
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Oncology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 26, 2026 (publication date) through Jan 26, 2026
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World Journal of Stem Cells
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1948-0210
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Klabukov ID, Kisel A, Yatsenko E, Sulina Y, Baranovskii DS. Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx. World J Stem Cells 2026; 18(1): 115655 [DOI: 10.4252/wjsc.v18.i1.115655]
World J Stem Cells. Jan 26, 2026; 18(1): 115655 Published online Jan 26, 2026. doi: 10.4252/wjsc.v18.i1.115655
Cancer cell-dependent increase in senescence-like populations following exosome treatment: The role of extracellular matrix and cellular glycocalyx
Ilya D Klabukov, Anastas Kisel, Elena Yatsenko, Yana Sulina, Denis S Baranovskii
Ilya D Klabukov, Anastas Kisel, Elena Yatsenko, Denis S Baranovskii, Department of Regenerative Medicine, National Medical Research Radiological Center, Obninsk 249036, Kaluzhskaya Oblast’, Russia
Ilya D Klabukov, Obninsk Institute for Nuclear Power Engineering, National Research Nuclear University MEPhI, Obninsk 249033, Kaluzhskaya Oblast’, Russia
Yana Sulina, Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Moskva, Russia
Denis S Baranovskii, Institute of Systems Biology and Medicine, Russian University of Medicine, Moscow 117997, Moskva, Russia
Author contributions: Klabukov ID designed and performed research, and wrote the manuscript; Kisel A, Sulina Y, and Baranovskii DS analyzed data; Yatsenko E revised the manuscript.
Supported by Russian Science Foundation, No. 24-64-00028.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ilya D Klabukov, PhD, Associate Professor, Head, Department of Regenerative Medicine, National Medical Research Radiological Center, 4 Koroleva Street, Obninsk 249036, Kaluzhskaya Oblast’, Russia. ilya.klabukov@gmail.com
Received: October 22, 2025 Revised: November 1, 2025 Accepted: December 5, 2025 Published online: January 26, 2026 Processing time: 90 Days and 16.2 Hours
Abstract
We read with the great interest the study by Ababneh et al in which induced mesenchymal stem cell-derived exosomes were shown to exhibit a stronger and more sustained anti-proliferative effect by inducing a senescence-like state without apoptosis. The results obtained by the authors highlight the features of the effects of senescent drift induction in surrounding tissues. In the light of these findings, the role of the properties of extracellular matrix and cellular glycocalyx in responses of human tumors to therapy remain uninvestigated. These extracellular barriers appear to be significant obstacles to effective cancer therapy, especially in relation to the use of unique properties of tumor microenvironment for the immunotherapy-resistant cancer treatment.
Core Tip: Extracellular vesicles can promote or inhibit oncogenic progression by shaping the tumor microenvironment. The efficiency of extracellular vesicle delivery can be affected by the extracellular matrix and altered glycocalyx. The tumor extracellular matrix and cellular glycocalyx can create a permissive niche for invasion, immune evasion, and metastasis. These factors are also essential for predicting the effectiveness of targeted therapies and the responses of bystander cells. Understanding these factors is crucial for treating cancers that are resistant to immunotherapies.
