Wang JJ, Xu HJ. Human umbilical cord mesenchymal stromal cell-derived extracellular vesicles alleviate radiation induced pulmonary fibrosis. World J Stem Cells 2025; 17(9): 111341 [DOI: 10.4252/wjsc.v17.i9.111341]
Corresponding Author of This Article
Hong-Jie Xu, PhD, Associate Professor, The Fifth Affiliated Hospital, Guangzhou Medical University, No. 188 Kaiyuan Avenue, Huangpu District, Guangzhou 510535, Guangdong Province, China. xuhongjie316@163.com
Research Domain of This Article
Cell Biology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Author contributions: Wang JJ and Xu HJ contributed to the manuscript writing; Xu HJ contributed to conceptualization and revision; Wang JJ contributed to language editing and financial support. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Jie Xu, PhD, Associate Professor, The Fifth Affiliated Hospital, Guangzhou Medical University, No. 188 Kaiyuan Avenue, Huangpu District, Guangzhou 510535, Guangdong Province, China. xuhongjie316@163.com
Received: July 4, 2025 Revised: July 21, 2025 Accepted: September 3, 2025 Published online: September 26, 2025 Processing time: 82 Days and 20.7 Hours
Core Tip
Core Tip: This commentary examines the study by Wang et al on the role of human umbilical cord mesenchymal stromal cell-derived exosomes in alleviating radiation induced pulmonary fibrosis. However, some issues are worth discussing. First, regarding the definitions of mesenchymal stromal cells and exosomes, according to the latest standards, mesenchymal stromal cell should represent mesenchymal stromal cell, and the so-called exosomes should be extracellular vesicles. Secondly, there are some imprecise or incorrect parts in the text that need to be clarified, especially the evidence for the AKT signaling pathway may be insufficient. Thirdly, this article more systematically discusses the current progress of extracellular vesicles in the treatment of pulmonary fibrosis.
