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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2025; 17(9): 109330
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.109330
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.109330
Exercise combined with induced pluripotent stem cells enhances the Wnt1-Lmx1a loop in the midbrain of Parkinsonian mice to alleviate Parkinsonian symptoms
Xing Jiang, Zhi-Min Lu, Jie Zhang, College of Medical Laboratory, Qilu Medical University, Zibo 250300, Shandong Province, China
Xing Jiang, Zhi-Min Lu, Qing-Lu Wang, College of Sport and Health, Shandong Sport University, Jinan 250102, Shandong Province, China
Ying Luo, Department of Clinical Laboratory, Zibo Central Hospital, Zibo 255000, Shandong Province, China
Co-first authors: Xing Jiang and Zhi-Min Lu.
Co-corresponding authors: Ying Luo and Jie Zhang.
Author contributions: Jiang X and Lu ZM contributed equally to this manuscript and are co-first authors. Jiang X, Lu ZM, and Luo Y conceived and designed research, performed experiment, and drafted manuscript; Jiang X and Lu ZM analyzed data, interpreted results of experiments, and prepared figures; Wang QL and Zhang J edited and revised manuscript. Luo Y and Zhang J contributed equally as co-corresponding author. All the authors have read and agreed to the published version of the manuscript and have agreed to be personally accountable for the author’s contributions and answer any questions related to the accuracy or integrity of any part of the work.
Supported by the Central Government Guides Local Science and Technology Development Funds, No. YDZX2022091; and General Program of Natural Sciences of Qilu Medical University, No. X24ZKQN03.
Institutional animal care and use committee statement: All animal experiments were approved by the Animal Experiment Ethics Committee of Shandong Sport University, No. 2023KY00012.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Details of the animal model construction are provided in the methods section and supporting information.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Zhang, PhD, College of Medical Laboratory, Qilu Medical University, No. 2018 Jiangmenglu Road, Zibo 250300, Shandong Province, China.
Received: May 9, 2025
Revised: June 18, 2025
Accepted: August 20, 2025
Published online: September 26, 2025
Processing time: 139 Days and 1.4 Hours
Revised: June 18, 2025
Accepted: August 20, 2025
Published online: September 26, 2025
Processing time: 139 Days and 1.4 Hours
Core Tip
Core Tip: This study explores the combined therapeutic effect of exercise and induced pluripotent stem cells (iPSCs) in a Parkinson’s disease mouse model. Exercise alone enhances motor function and activates the Wnt signaling pathway, increasing adrenaline and Wnt1 levels. Combining exercise with iPSC treatment further boosts the Wnt1-Lmx1a regulatory loop, promoting iPSC differentiation into dopaminergic neurons and significantly improving motor function.