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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2025; 17(9): 107689
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.107689
Published online Sep 26, 2025. doi: 10.4252/wjsc.v17.i9.107689
Neural crest-derived mesenchymal stem cells: Fates and perspectives
Yi-Lin He, Department of General Dentistry and Emergency Dental Care, Beijing Stomatological Hospital, Beijing 100050, China
Si-Jia Chen, Department of Oral and Maxillofacial Plastic and Traumatic Surgery, Beijing Stomatological Hospital, Beijing 100050, China
Deng-Sheng Xia, Department of General Dentistry and Integrated Emergency Dental Care, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China
Wen-Peng Song, Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Co-first authors: Yi-Lin He and Si-Jia Chen.
Co-corresponding authors: Deng-Sheng Xia and Wen-Peng Song.
Author contributions: He YL and Chen SJ contributed equally to this manuscript and are co-first authors of this manuscript. Xia DS and Song WP contributed equally to this manuscript and are co-corresponding authors of this manuscript. He YL and Song WP contributed to the data collection and manuscript writing; Chen SJ, Xia DS, and Song WP contributed to the study design and supervision. All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82270951.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Peng Song, DDS, Postdoc, Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing 100070, China. 15011482782@163.com
Received: March 28, 2025
Revised: April 25, 2025
Accepted: August 8, 2025
Published online: September 26, 2025
Processing time: 180 Days and 16.2 Hours
Revised: April 25, 2025
Accepted: August 8, 2025
Published online: September 26, 2025
Processing time: 180 Days and 16.2 Hours
Core Tip
Core Tip: Recent studies have revealed the distribution and functions of neural crest (NC)-derived mesenchymal stem cells (MSCs) in various tissues, with regenerative therapies based on these cells showing positive results in research and clinical practice. Future research focuses on optimizing therapeutic strategies (timing, dosage), expanding clinical applications, and addressing current challenges. Several approaches aim to solve issues like insufficient cell numbers, heterogeneity, and trauma. Notably, MSCs differentiated from pluripotent stem cells via NC pathways show promise as a stable NC-derived MSC source, potentially overcoming current limitations in clinical applications.