©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2025; 17(5): 106150
Published online May 26, 2025. doi: 10.4252/wjsc.v17.i5.106150
Published online May 26, 2025. doi: 10.4252/wjsc.v17.i5.106150
Effect of adipokines on bone marrow mesenchymal stem cell function
Rui-Ming Wen, School of Sports Health, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Hai-Xia Wang, College of Exercise and Health, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Co-first authors: Rui-Ming Wen and Hai-Xia Wang.
Author contributions: Wen RM prepared the figures and wrote the manuscript; Wang HX performed data acquisition, wrote, conceptualized, and provided input in writing the paper.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Corresponding author: Hai-Xia Wang, PhD, College of Exercise and Health, Shenyang Sport University, No. 36 Jinqiansong East Road, Shenyang 110102, Liaoning Province, China.
Received: February 24, 2025
Revised: March 23, 2025
Accepted: April 9, 2025
Published online: May 26, 2025
Processing time: 98 Days and 5.5 Hours
Revised: March 23, 2025
Accepted: April 9, 2025
Published online: May 26, 2025
Processing time: 98 Days and 5.5 Hours
Core Tip
Core Tip: Recent studies have shown that adipokines can play an important role in skeletal system repair and regeneration by regulating bone marrow-derived mesenchymal stem cell (BMSC) proliferation, differentiation, migration, and immune regulation. This review summarizes and elaborates on the specific mechanisms of action and potential clinical application prospects of the adipokines visfatin, chemerin, vaspin, and adiponectin on BMSC function. The aim is to reveal new pathways of interaction between adipokines and BMSCs and provide theoretical support for targeted adipokine-based bone disease treatment strategies.