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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2025; 17(12): 113456
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.113456
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.113456
Advancing human adipose-derived mesenchymal stem cell-derived exosomes for androgenetic alopecia: Appraisal and methodological recommendations
Yu Jiang, Department of Emergency Medicine, The Traditional Chinese Medicine Hospital of Longquanyi, Chengdu 610100, Sichuan Province, China
Wen-Jun Huang, Rui Zhou, Shaanxi Institute for Pediatric Diseases, Affiliated Children’s Hospital of Xi’an Jiaotong University, Xi’an 710003, Shaanxi Province, China
Author contributions: Jiang Y was responsible for drafting the manuscript; Huang WJ carried out proofreading and formatting checks; Zhou R contributed to the conceptualization, supervision, and proofreading of the manuscript. All authors have reviewed and approved the final version for publication.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui Zhou, PhD, Associate Professor, Shaanxi Institute for Pediatric Diseases, Affiliated Children’s Hospital of Xi’an Jiaotong University, No. 69 West Juyuan Lane, Lianhu District, Xi’an 710003, Shaanxi Province, China. zhouhuaxizhu@126.com
Received: September 3, 2025
Revised: September 30, 2025
Accepted: November 21, 2025
Published online: December 26, 2025
Processing time: 113 Days and 14.7 Hours
Revised: September 30, 2025
Accepted: November 21, 2025
Published online: December 26, 2025
Processing time: 113 Days and 14.7 Hours
Core Tip
Core Tip: Key challenges for translating human adipose-derived mesenchymal stem cell-derived exosomes in androgenetic alopecia include: Incomplete exosome marker information; lack of standardized reporting for particle counts and protein content; absence of direct CDC42 function validation; limited depth in Wnt/β-catenin pathway analysis; insufficient biochemical data in animal models; undefined microneedle delivery parameters; limited safety profiling; and lack of integrated quality control and potency release criteria.