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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2025; 17(12): 112207
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.112207
Published online Dec 26, 2025. doi: 10.4252/wjsc.v17.i12.112207
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p
Zi-Feng Zeng, Jin Rao, Xi-Bei Xia, Xiang-Yu Chen, Yu-Di Liu, Guo-Ji Wang, Peng-Chao Cheng, Jun-Nan Wang, Pei Wang, Yue Yu, Zhi-Nong Wang, Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
Hong-Xiang He, School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai 200135, China
Bin Liu, Naval Medical Center, Naval Medical University, Shanghai 200433, China
Qiong Chen, Precision Medical Center of Nanfang Hospital, Southern Medical University, Guangzhou 510405, Guangdong Province, China
Co-first authors: Zi-Feng Zeng and Jin Rao.
Co-corresponding authors: Yue Yu and Zhi-Nong Wang.
Author contributions: Zeng ZF, Rao J, Xia XB, and Chen XY performed the experiments and wrote the paper; He HX, Liu B, Chen Q, Liu YD, and Wang GJ acquired and analyzed the data; Cheng PC, Wang JN, and Wang P contributed to the conceptualization and supervision; Yu Y and Wang ZN were engaged in the design of the study and the revision of the manuscript; Yu Y and Wang ZN participated equally and shared the corresponding authorship; All authors read and approved the version of the article to be published. Zeng ZF and Rao J made equal contributions to this article as co-first authors.
Institutional review board statement: Human umbilical cord-derived mesenchymal stem cells were provided by the Precision Medical Center of Nanfang Hospital, with the informed consent of all participants and approved by the Medical Ethics Committee of the hospital (Approval No. NFEC-202110-K17-01).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Nong Wang, PhD, Professor, Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. wangzn007@smmu.edu.cn
Received: July 22, 2025
Revised: August 25, 2025
Accepted: November 14, 2025
Published online: December 26, 2025
Processing time: 157 Days and 2 Hours
Revised: August 25, 2025
Accepted: November 14, 2025
Published online: December 26, 2025
Processing time: 157 Days and 2 Hours
Core Tip
Core Tip: Hypoxic preconditioning enhances the therapeutic properties of mesenchymal stem cell-derived exosomes with elevated miR-486-5p, which directly inhibits phosphatase and tensin homolog to activate the phosphoinositide 3-kina