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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Oct 26, 2025; 17(10): 109862
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.109862
Published online Oct 26, 2025. doi: 10.4252/wjsc.v17.i10.109862
Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling
Asmaa M ShamsEldeen, Department of Physiology, Cairo University, Cairo 30411, Egypt
Manar M AbdElalim, Nahed S Mohamed, Marwa M AbdelRahman, Asmaa M Selmy, Department of Physiology, Faculty of Medicine, Cairo University, Cairo 30411, Egypt
Samaa S Kamar, Department of Histology, Cairo University, Cairo 30411, Egypt
Samaa S Kamar, Department of Histology, Armed Forces College of Medicine, Cairo 11766, Al Qāhirah, Egypt
Dina H AbdelKader, Department of Histology, Kasr Al-Ainy Faculty of Medicine, Cairo 30411, Egypt
Samar H Elsharkawy, Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Giza 12613, Al Jīzah, Egypt
Laila A Rashed, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo 30411, Egypt
Salwa S Faisal, Department of Biochemistry and Molecular Biology, Suez Canal University, Ismailia 41511, Egypt
Walla’a A Osman, Department of Pharmacology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo 30411, Al Qāhirah, Egypt
Co-corresponding authors: Asmaa M ShamsEldeen and Samaa S Kamar.
Author contributions: ShamsEldeen AM, AbdElalim MM, Mohamed NS, AbdelRahman MM, Kamar SS, and Selmy AM designed and coordinated the study; AbdElalim MM, AbdelRahman MM, Osman WA, and Selmy AM performed the experiments; ShamsEldeen AM, AbdElalim MM, Mohamed NS, AbdelRahman MM, Kamar SS, AbdelKader DH, Elsharkawy SH, Rashed LA, Faisal SS, Osman WA, and Selmy AM acquired, analyzed and interpreted the data; AbdelRahman MM, Kamar SS, Faisal SS, Osman WA, and Selmy AM wrote the manuscript draft; ShamsEldeen AM, Mohamed NS, AbdelRahman MM, Kamar SS, and Selmy AM reviewed and edited the final manuscript version; ShamsEldeen AM and Kamar SS contributed equally to this manuscript and are co-corresponding authors. All authors approved the final version of the article.
Institutional animal care and use committee statement: The current study was approved by the Institutional Animal Care and Use Committee of Cairo University (Approval No. CU/III/F/59/20).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available. All data generated or analyzed during this study are included in this published article and its supplementary information file.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Asmaa M ShamsEldeen, MD, Assistant Professor, Department of Physiology, Cairo University, Al-Saray Street, El Manial, Cairo 30411, Egypt.
Received: May 26, 2025
Revised: June 19, 2025
Accepted: September 8, 2025
Published online: October 26, 2025
Processing time: 154 Days and 13.8 Hours
Revised: June 19, 2025
Accepted: September 8, 2025
Published online: October 26, 2025
Processing time: 154 Days and 13.8 Hours
Core Tip
Core Tip: Myocardial infarction has been extensively validated in rats for reliably inducing post-infarction metabolic and histological changes. Combined therapy may target the extracellular signal-regulated kinase and protein kinase B/mammalian target of rapamycin signaling, both of which are central to the development of hypertrophic remodeling after myocardial infarction, along with the crosstalk between matrix metalloproteinase 9 and sarcoplasmic endoplasmic reticulum calcium ATPase type 2a, which maintains the balance between hypertrophic growth and contractile function. This could offer a new therapeutic regimen for treating early maladaptive left ventricular hypertrophy.