Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization
Fei Liu, Jing Xiao, Lei-Hui Chen, Yu-Yue Pan, Jun-Zhang Tian, Zhi-Ren Zhang, Xiao-Chun Bai
Fei Liu, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Fei Liu, Jun-Zhang Tian, Department of Health Management, Guangdong Second Provincial General Hospital, Guangzhou 510317, Guangdong Province, China
Jing Xiao, Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People’s Hospital Affiliated with Jinan University, Zhuhai 519000, Guangdong Province, China
Jing Xiao, Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Macau 999078, China
Lei-Hui Chen, Yu-Yue Pan, Department of Stomatology, Guangdong Second Provincial General Hospital, Guangzhou 510317, Guangdong Province, China
Zhi-Ren Zhang, Zhuhai Institute of Translational Medicine, Zhuhai Hospital Affiliated with Jinan University, Zhuhai 519000, Guangdong Province, China
Xiao-Chun Bai, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Co-first authors: Fei Liu and Jing Xiao.
Co-corresponding authors: Zhi-Ren Zhang and Chun-Xiao Bai.
Author contributions: Liu F, Xiao J, Tian JZ, Zhang ZR, and Bai XC designed the research; Liu F and Xiao J performed the research and analyzed the data; Chen LH and Pan YY contributed human dental pulp tissue; Liu F wrote the paper. Liu F and Xiao J contributed to the work equally and should be regarded as co-first authors. Bai XC and Zhang ZR contributed to the work equally and should be regarded as co-corresponding author.
Supported by the Science and Technology Programme of Guangzhou City, No. 202201020341.
Institutional review board statement: This study was approved by the Ethics Committee of Guangdong Second Provincial General Hospital.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at
kqliufei@126.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xiao-Chun Bai, PhD, Professor, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, No. 1023-1063 Shatai South Road, Baiyun District, Guangzhou 510515, Guangdong Province, China.
baixc15@smu.edu.cn
Received: December 19, 2023
Peer-review started: December 19, 2023
First decision: January 12, 2024
Revised: January 21, 2024
Accepted: February 28, 2024
Article in press: February 28, 2024
Published online: March 26, 2024
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