Gao Y, Wu RQ, Lv Y, Yan XP. Novel magnetic compression technique for establishment of a canine model of tracheoesophageal fistula. World J Gastroenterol 2019; 25(30): 4213-4221 [PMID: 31435174 DOI: 10.3748/wjg.v25.i30.4213]
Corresponding Author of This Article
Xiao-Peng Yan, PhD, Doctor, Surgeon, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Xi’an 710061, Shannxi Province, China. yanxiaopeng99@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Gao Y, Wu RQ, Lv Y, Yan XP. Novel magnetic compression technique for establishment of a canine model of tracheoesophageal fistula. World J Gastroenterol 2019; 25(30): 4213-4221 [PMID: 31435174 DOI: 10.3748/wjg.v25.i30.4213]
World J Gastroenterol. Aug 14, 2019; 25(30): 4213-4221 Published online Aug 14, 2019. doi: 10.3748/wjg.v25.i30.4213
Novel magnetic compression technique for establishment of a canine model of tracheoesophageal fistula
Yi Gao, Rong-Qian Wu, Yi Lv, Xiao-Peng Yan
Yi Gao, Yi Lv, Xiao-Peng Yan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shannxi Province, China
Yi Gao, Rong-Qian Wu, Yi Lv, Xiao-Peng Yan, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shannxi Province, China
Author contributions: Yan XP and Lv Y designed the study; Gao Y and Yan XP performed the research and acquired the data; Gao Y and Yan XP analyzed the data; Yan XP, Gao Y, and Wu RQ drafted the manuscript; Gao Y, Wu RQ, Lv Y, and Yan XP contributed significantly to the revision of the manuscript.
Supported bythe National Natural Science Foundation of China, No. 81700545; the Natural Science Basic Research Plan of Shaanxi Province of China, No. 2017JQ8021; and the Fundamental Research Funds for the Central Universities, No. xjj2018jchz14.
Institutional review board statement: This study was approved by the Institutional Review Board of the First Affiliated Hospital of Xi’an Jiaotong University.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the First Affiliated Hospital of Xi’an Jiaotong University.
Conflict-of-interest statement: The authors declare no conflict of interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The ARRIVE Guidelines have been adopted.
Corresponding author: Xiao-Peng Yan, PhD, Doctor, Surgeon, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Xi’an 710061, Shannxi Province, China. yanxiaopeng99@163.com
Telephone: +86-29-82657541
Received: April 8, 2019 Peer-review started: April 8, 2019 First decision: May 30, 2019 Revised: July 4, 2019 Accepted: July 5, 2019 Article in press: July 5, 2019 Published online: August 14, 2019 Processing time: 129 Days and 22.9 Hours
ARTICLE HIGHLIGHTS
Research background
Tracheoesophageal fistula in children is a rare human disease worldwide. To date, there is no ideal surgical strategy for the disease. The main reason is due to the lack of ideal animal models to mimic this disease.
Research motivation
The magnetic compression technique has been used to prepare the animal model of digestive tract anastomosis or vascular anastomosis. Therefore, we tried to use this new technique to establish a novel model mimicking tracheoesophageal fistula in children, hoping to provide a new surgical strategy for this disease.
Research objectives
To establish a canine model of tracheoesophageal fistula using the magnetic compression technique.
Research methods
Using a magnetic device consisting of daughter and parent Nd-Fe-B permanent magnets, a tracheoesophageal fistula model was established in male beagles through placing the device in the cervical esophagus. After 4~6 days of operation, gastroscopy/bronchoscopy, esophageal angiography, and histological analysis were carried out to identify the model.
Research results
After the operation, the esophageal mucosa and pseudostratified ciliated columnar epithelium were absent at the site of the fistula in the beagle model of tracheoesophageal fistula. Mean operating time was 4.33 ± 1.11 min, and mean time for successful establishment of the tracheoesophageal fistula model was 4.67 ± 0.75 d.
Research conclusions
A simple, minimally invasive, and feasible model of tracheoesophageal fistula in canine was first established by using the novel magnetic compression technique.
Research perspectives
Although providing a suitable model similar to tracheoesophageal fistula in children, the feasibility, applicability, safety, and efficacy of new surgical treatment for tracheoesophageal fistula using the specific model need to be explored in future studies.
