Metformin abuse and weight loss: A case report

Table 1 Patient’s laboratory findings

	May 26, 2022 (initial presentation)	Day 1 (August 24, 2022)	Day 2 (August 25, 2022)	Day 3 (August 26, 2022)	Day 4 (August 27, 2022)	Day 5 (August 28, 2022)
Hemoglobin (Reference: 12-16 g/dL)				10.6	10.0	10.5
Mean corpuscular volume (Reference: 78-96 fL)				93	92	91
Sodium (Reference: 135-145 mmol/L)	138	135	132		135	134
Potassium (Reference: 3.5-5.0 mmol/L)	3.5	4.9	3.5		3.2	3.4
Chloride (Reference: 98-107 mmol/L)	112
Potential of hydrogen	7.28	6.97	7.21	7.36	7.42
Bicarbonate (Reference 22-28 mEq/L)	12.0	2.0	5.1	12.8	20.3
Partial pressure of carbon dioxide (Reference: 35-45 mmHg)	30.0	8.9	12.7	22.3	31.1
Partial pressure of oxygen (Reference: 75 to 100 mmHg)					43
Creatinine (Reference: 0.6-1.2 mg/dL)	1.00	6.02		3.21	4.15	4.92
Urea (Reference: 7-20 mg/dL)	33	109		62	79	93
Serum ketones (Reference: Negative)	Positive
C-reactive protein (Reference: < 0.5 mg/dL)		0.43	1.21	4.54	4.59	5.18
Procalcitonin (Reference: Up to 0.5 ng/dL)			1.03		0.34
Lactate dehydrogenase (Reference: 60-248 U/L)			327	309	358
Venous lactic acid (Reference: 4.5-19.8 mg/dL)			27
Amylase (Reference: 0-120 U/L)		412		1377	986
Lipase (Reference: 10-55 U/L)				3360
Alanine aminotransferase (Reference: 0-40 U/L)		25	23
Aspartate aminotransferase (Reference: 0-40 U/L)			27		35
Albumin (Reference: 3.2-5.0 g/dL)			3.4	2.9	2.8
Globulin (Reference: 2.7-3.3 g/dL)			2.5	1.7	1.9
Total proteins (Reference: 6.4-8.3 g/dL)			5.9	4.6	4.7
Prothrombin time (Reference: 11-15 Seconds)			17.8
Partial thromboplastin time (Reference: 25-40 Seconds)
International normalized ratio (Reference: 0.8-1.2)		3.4	1.53
Lactate level (Reference: 0.5-2.2 mmol/L)		9.5

Table 2 Patient’s laboratory findings

	Day 6 (August 29, 2022)	Day 7 (August 30, 2022)	Day 8 (August 31, 2022)	Day 11 (September 3, 2022)	Day 19 (September 11, 2022)
Amylase (Reference: 0-104 U/L)	410		342		228
Creatinine (Reference: 0.6-1.2 mg/dL)	5.32	5.53	5.77	2.99	0.75
Urea (Reference: 7-20 mg/dL)	96	90	91	63	17
Alanine transaminase (Reference: 0-40 U/L)	753	1186	775	204	35
Aspartate aminotransferase (Reference: 0-40 U/L)			297		17
Bilirubin (Total, direct) (Reference: Total 2.0-1.2 mg/dL, direct 0-0.3 mg/dL)		Total: 1.16; Direct: 0.94
Albumin (Reference: 3.2-5.0 g/dL)	135.0				3.6
Globulin (Reference: 2.7-3.3 g/dL)	3.6
Total proteins (Reference: 6.4-8.3 g/dL)	4.6
Prothrombin time (Reference: 11-15 Seconds)	34.9	19.7	17.7
Partial thromboplastin time (Reference: 25-40 Seconds)	39	37	32
International normalized ratio (Reference: 0.8-1.2)	3.40	1.73	1.52
Bicarbonate (Reference 22-28 mEq/L)
Partial pressure of oxygen (Reference: 75-100 mmHg)
C-reactive protein (Reference: < 0.5 mg/dL)		4.52	4.49		1.13
Procalcitonin (Reference: Up to 0.5 ng/dL)		71.2	33.6
Sodium (Reference: 135-145 mmol/L)		135.0	133.0	133.0	146.6
Potassium (Reference: 3.5-5.0 mmol/L)		3.90	3.70	2.64	4.57