Primary signet ring cell carcinoma of the female urethra: A case report

Table 1 Reported cases of primary signet ring cell carcinoma of the urethra in women

No.	Age (years)	Symptoms	Symptom duration	Location and extent of tumors at presentation	Stage (TNM)	Treatment	Follow up	Status
Suzuki et al[6]	70	Frequency, difficulty in urination, nocturia and acute retention	6 weeks	Urethral mass fixed to the symphysis pubis, vagina and bladder neck with left inguinal lymph node metastasis	T4N1 or 2 M0	Radiotherapy. Anterior exenteration and left inguinal lymph node dissection. Palliative chemotherapy	18 months	DOD
Suzuki et al[6]	66	Frequency and bloody vaginal discharge	9 months	Entire urethra, anterior vaginal wall, pelvic side walls and bladder neck with right inguinal lymph node metastasis	T3N1 or 2 M0	No treatment	6 months	Presumably DOD
Suzuki et al[6]	72	Enlarging mass at the external urethral meatus and yellowish discharge	4-6 months	Polypoid tumor at the external urethral meatus	TaN0M0	Wide local excision (2 cm of distal urethra, urethral meatus and anterior vulva) and bilateral inguinal lymph node dissection	7 months	NED
Suzuki et al[6]	69	Difficulty in urination and bloody fluid from urethra	24 months	Anterior vaginal wall and bladder neck	T3N0M0	Total cysto-urethrectomy and hysterectomy with bloody fluid pelvic lymph node dissection	17 months	NED
Grimsby et al[5]	81	Suprapubic pain, urethral discharge, urinary frequency, urgency, and stranguria	No report	A firm tender mass at 7 o’clock in the urethra	T4N0M0	Robotic assisted radical cystectomy, bilateral pelvic lymph node dissection	1 month	DOD
6 (present case)	61	Irregular vaginal bleeding	2 months	2 cm mass situated at the urethral orifice	T1N0M0	Distal urethral resection	12 months	NED

DOD: Died of disease; NED: No evidence of disease.