Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2025; 13(27): 107158
Published online Sep 26, 2025. doi: 10.12998/wjcc.v13.i27.107158
Primary signet ring cell carcinoma of the female urethra: A case report
Pan Xu, Shan-Shan Ling, E Hu, Bi-Xia Yi
Pan Xu, Shan-Shan Ling, E Hu, Bi-Xia Yi, Department of Gynecology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua 321000, Zhejiang Province, China
Pan Xu, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China
Co-first authors: Pan Xu and Shan-Shan Ling.
Author contributions: Xu P and Ling SS contributed equally to this work and wrote the main manuscript; Hu E prepared the figures; Xu P and Yi BX revised the final manuscript; All authors have read and approved the final manuscript.
Supported by the Science and Technology Bureau Foundation of Jinhua, No. 2021-4-300 and No. 2020-3-062; and The Zhejiang Provincial Medical and Health Science and Technology Plan, No. 2025KY1752.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest in relation to this case report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pan Xu, MD, Director, Department of Gynecology, Affiliated Jinhua Hospital of Wenzhou Medical University, No. 267 Danxi East Street, Jinhua 321000, Zhejiang Province, China. xupan033@163.com
Received: March 21, 2025
Revised: May 21, 2025
Accepted: June 20, 2025
Published online: September 26, 2025
Processing time: 137 Days and 5 Hours
Core Tip

Core Tip: Primary signet ring cell carcinoma of the urethra in women is an exceedingly rare malignancy. A 61-year-old woman presented with irregular vaginal bleeding. She was found to have a tumor located in the distal urethra. Based upon a diagnosis of primary urethral carcinoma, she underwent distal urethrectomy. Microscopically, the tumor was composed of intestinal adenocarcinoma and signet ring cell carcinoma. No recurrence was observed 12 months after surgery.