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©The Author(s) 2025.
World J Clin Cases. Sep 6, 2025; 13(25): 107907
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.107907
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.107907
Table 1 Effects of nitric oxide on lung cancer models
Factor | Models | Effects | Ref. |
Nitric oxide | H460 cell line | Migratory | [40] |
LLC-1 cell line | Apoptotic | [41] | |
Lung cancer patient | Tumorigenic | [42] | |
Lung cancer tissue | Anti-apoptotic | [43] | |
NCI-H292 cell line | Anti-apoptotic | [44] | |
H23 cell line | Migratory | [45] | |
Lung cancer patient | Tumorigenic | [46] | |
H292 and H460 cell lines | Tumorigenic | [47] | |
H23, H292, and H460 cell lines | Migratory | [48] | |
Anoikis-resistant H460 cell line | Metastatic | [49] | |
A549, H1299, and CL3 cell lines | Apoptotic | [50] | |
Cisplatin-resistant A549 cells | Drug resistance | [51] | |
KRAS mutation-positive mice | Growth | [52] | |
A549 and H3255 cell lines | Radiation resistance | [53] | |
- | Stemness maintenance | [54] | |
LUAD patient | Tumorigenic | [55] |
Table 2 Levels of nitric oxide on lung cancer models
Table 3 Effects of prostaglandins on lung cancer models
Factor | Models | Effects | Ref. |
Prostaglandin D2 | A549 cell line | Apoptosis | [65] |
Prostaglandin I2 | A549 cell line | Anti-growth | [66] |
LLC | Anti-metastatic | [67] | |
LLC | Anti-metastatic | [68] | |
Transgenic mice | Chemopreventive | [69] | |
Prostaglandin E2 | NSCLC | Growth | [70] |
A549 and PC-9 cell lines | Pro-tumorigenic | [71] | |
A549 and GLC82 cell lines | Proliferative | [72] | |
NSCLC cell line | Apoptosis resistance | [73] | |
A549 cell line | Anti-apoptotic | [74] | |
A549 cell line and lung cancer mice | Multidrug resistance | [75] | |
Lung cancer patients | Tumorigenic | [76] | |
A549 cell line | Migratory | [77] | |
NSCLC cell line | Invasive | [78] | |
A549 cell line | Tumorigenic | [79] | |
NSCLC cell line | Proliferative | [80] | |
NSCLC cells | Metastatic | [81] | |
NCI-H157 cell line | Angiogenic | [82] | |
NSCLC patients | Immunosuppressive | [83] | |
A549 cell line | Migratory | [84] |
Table 4 Levels of prostaglandins on lung cancer models
Factor | Models | Levels | Ref. |
Prostaglandin D2 | Lung cancer tissue | Low | [85] |
NSCLC | Low | [86] | |
Prostaglandin I2 | Lung cancer patient | Low | [87] |
neoplastic cell | Low | [88] | |
Lung cancer patient | High | [89] | |
Lung tumor tissue | Low | [90] | |
Prostaglandin E2 | lung cancer tissue | High | [91] |
NSCLC cell line | High | [92] | |
Lung cancer tissue | High | [85] | |
Lung cancer patient | high | [93] | |
NSCLC patient | High | [94] | |
8-Iso-prostaglandin F2α | Lung cancer patient | High | [95] |
Lung cancer patient | High | [96] | |
NSCLC patient | High | [97] | |
Lung cancer patient | High | [98] | |
NSCLC patient | High | [99] |
Table 5 Effects of thromboxanes on lung cancer
Table 6 Levels of thromboxanes on lung cancer models
Table 7 Effects of endothelins on lung cancer models
Table 8 Levels of endothelins on lung cancer models
- Citation: Demirel S, Sinag IN. Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview. World J Clin Cases 2025; 13(25): 107907
- URL: https://www.wjgnet.com/2307-8960/full/v13/i25/107907.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v13.i25.107907