Review
Copyright ©The Author(s) 2025.
World J Clin Cases. Sep 6, 2025; 13(25): 107907
Published online Sep 6, 2025. doi: 10.12998/wjcc.v13.i25.107907
Table 1 Effects of nitric oxide on lung cancer models
Factor
Models
Effects
Ref.
Nitric oxideH460 cell lineMigratory [40]
LLC-1 cell lineApoptotic [41]
Lung cancer patientTumorigenic[42]
Lung cancer tissueAnti-apoptotic[43]
NCI-H292 cell lineAnti-apoptotic[44]
H23 cell lineMigratory[45]
Lung cancer patientTumorigenic[46]
H292 and H460 cell lines Tumorigenic[47]
H23, H292, and H460 cell linesMigratory[48]
Anoikis-resistant H460 cell lineMetastatic[49]
A549, H1299, and CL3 cell linesApoptotic[50]
Cisplatin-resistant A549 cellsDrug resistance[51]
KRAS mutation-positive miceGrowth [52]
A549 and H3255 cell linesRadiation resistance[53]
-Stemness maintenance[54]
LUAD patientTumorigenic[55]
Table 2 Levels of nitric oxide on lung cancer models
Factor
Models
Levels
Ref.

Nitric oxide
Lung cancer patientHigh[56]
NSCLC patientHigh[57]
Lung cancer patientHigh[58]
Lung cancer patientHigh[59]
Lung cancer patientHigh[60]
Lung cancer patientHigh[61]
Lung cancer tissueHigh[62]
Lung cancer patientHigh[63]
NSCLC tissueLow[64]
Squamous cell carcinoma tissueHigh
Table 3 Effects of prostaglandins on lung cancer models
Factor
Models
Effects
Ref.
Prostaglandin D2A549 cell lineApoptosis [65]
Prostaglandin I2A549 cell lineAnti-growth[66]
LLC Anti-metastatic [67]
LLCAnti-metastatic [68]
Transgenic miceChemopreventive[69]
Prostaglandin E2NSCLCGrowth[70]
A549 and PC-9 cell linesPro-tumorigenic[71]
A549 and GLC82 cell linesProliferative[72]
NSCLC cell lineApoptosis resistance[73]
A549 cell line Anti-apoptotic [74]
A549 cell line and lung cancer miceMultidrug resistance[75]
Lung cancer patientsTumorigenic[76]
A549 cell lineMigratory[77]
NSCLC cell lineInvasive[78]
A549 cell lineTumorigenic [79]
NSCLC cell lineProliferative[80]
NSCLC cellsMetastatic [81]
NCI-H157 cell lineAngiogenic[82]
NSCLC patientsImmunosuppressive [83]
A549 cell lineMigratory[84]
Table 4 Levels of prostaglandins on lung cancer models
Factor
Models
Levels
Ref.
Prostaglandin D2Lung cancer tissueLow[85]
NSCLCLow[86]
Prostaglandin I2Lung cancer patientLow[87]
neoplastic cellLow[88]
Lung cancer patientHigh[89]
Lung tumor tissue Low[90]
Prostaglandin E2lung cancer tissue High [91]
NSCLC cell lineHigh[92]
Lung cancer tissueHigh[85]
Lung cancer patienthigh[93]
NSCLC patientHigh [94]
8-Iso-prostaglandin FLung cancer patient High[95]
Lung cancer patient High[96]
NSCLC patientHigh [97]
Lung cancer patientHigh[98]
NSCLC patientHigh[99]
Table 5 Effects of thromboxanes on lung cancer
Factor
Models
Effects
Ref.
Thromboxane A2NCI-H23 and A549 cell linesProliferative[100]
A549 cell lineInvasive [101]
H157 cell lineProliferative [102]
A549 cell lineGrowth and angiogenesis[103]
PC-9 and PC-9/CDDP cell linesAnti-apoptotic[104]
Table 6 Levels of thromboxanes on lung cancer models
Factor
Models
Levels
Ref.
Thromboxane A2NCI-H23, NCI-H460, and A549 cell linesHigh[100]
Thromboxane B2A549 cell lineHigh[105]
NSCLC tissueHigh[106]
NSCLC patientHigh[107]
Table 7 Effects of endothelins on lung cancer models
Factor
Models
Effects
Ref.
Endothelin-1A549 cell lineProliferative and invasive[108]
SPC-A1 cell lineProliferative[109]
Endothelin-2A549 cell lineAnti-apoptotic[110]
Table 8 Levels of endothelins on lung cancer models
Factor
Models
Levels
Ref.
Endothelin-1NSCLC tissueHigh[111]
COR-L88 and A549 cell lines High[112]
NSCLC patientHigh[113]
NSCLC patientHigh [114]
Endothelin-2LUAD tissueHigh[110]