Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview

Table 1 Effects of nitric oxide on lung cancer models

Factor	Models	Effects	Ref.
Nitric oxide	H460 cell line	Migratory	[40]
	LLC-1 cell line	Apoptotic	[41]
	Lung cancer patient	Tumorigenic	[42]
	Lung cancer tissue	Anti-apoptotic	[43]
	NCI-H292 cell line	Anti-apoptotic	[44]
	H23 cell line	Migratory	[45]
	Lung cancer patient	Tumorigenic	[46]
	H292 and H460 cell lines	Tumorigenic	[47]
	H23, H292, and H460 cell lines	Migratory	[48]
	Anoikis-resistant H460 cell line	Metastatic	[49]
	A549, H1299, and CL3 cell lines	Apoptotic	[50]
	Cisplatin-resistant A549 cells	Drug resistance	[51]
	KRAS mutation-positive mice	Growth	[52]
	A549 and H3255 cell lines	Radiation resistance	[53]
	-	Stemness maintenance	[54]
	LUAD patient	Tumorigenic	[55]

LLC-1: Lewis lung carcinoma; LUAD: Lung adenocarcinoma.

Table 2 Levels of nitric oxide on lung cancer models

Factor	Models	Levels	Ref.
Nitric oxide	Lung cancer patient	High	[56]
	NSCLC patient	High	[57]
	Lung cancer patient	High	[58]
	Lung cancer patient	High	[59]
	Lung cancer patient	High	[60]
	Lung cancer patient	High	[61]
	Lung cancer tissue	High	[62]
	Lung cancer patient	High	[63]
	NSCLC tissue	Low	[64]
	Squamous cell carcinoma tissue	High

NSCLC: Non-small cell lung cancer.

Table 3 Effects of prostaglandins on lung cancer models

Factor	Models	Effects	Ref.
Prostaglandin D2	A549 cell line	Apoptosis	[65]
Prostaglandin I2	A549 cell line	Anti-growth	[66]
	LLC	Anti-metastatic	[67]
	LLC	Anti-metastatic	[68]
	Transgenic mice	Chemopreventive	[69]
Prostaglandin E2	NSCLC	Growth	[70]
	A549 and PC-9 cell lines	Pro-tumorigenic	[71]
	A549 and GLC82 cell lines	Proliferative	[72]
	NSCLC cell line	Apoptosis resistance	[73]
	A549 cell line	Anti-apoptotic	[74]
	A549 cell line and lung cancer mice	Multidrug resistance	[75]
	Lung cancer patients	Tumorigenic	[76]
	A549 cell line	Migratory	[77]
	NSCLC cell line	Invasive	[78]
	A549 cell line	Tumorigenic	[79]
	NSCLC cell line	Proliferative	[80]
	NSCLC cells	Metastatic	[81]
	NCI-H157 cell line	Angiogenic	[82]
	NSCLC patients	Immunosuppressive	[83]
	A549 cell line	Migratory	[84]

NSCLC: Non-small cell lung cancer; LLC-1: Lewis lung carcinoma.

Table 4 Levels of prostaglandins on lung cancer models

Factor	Models	Levels	Ref.
Prostaglandin D2	Lung cancer tissue	Low	[85]
	NSCLC	Low	[86]
Prostaglandin I2	Lung cancer patient	Low	[87]
	neoplastic cell	Low	[88]
	Lung cancer patient	High	[89]
	Lung tumor tissue	Low	[90]
Prostaglandin E2	lung cancer tissue	High	[91]
	NSCLC cell line	High	[92]
	Lung cancer tissue	High	[85]
	Lung cancer patient	high	[93]
	NSCLC patient	High	[94]
8-Iso-prostaglandin F2α	Lung cancer patient	High	[95]
	Lung cancer patient	High	[96]
	NSCLC patient	High	[97]
	Lung cancer patient	High	[98]
	NSCLC patient	High	[99]

NSCLC: Non-small cell lung cancer.

Table 5 Effects of thromboxanes on lung cancer

Factor	Models	Effects	Ref.
Thromboxane A2	NCI-H23 and A549 cell lines	Proliferative	[100]
	A549 cell line	Invasive	[101]
	H157 cell line	Proliferative	[102]
	A549 cell line	Growth and angiogenesis	[103]
	PC-9 and PC-9/CDDP cell lines	Anti-apoptotic	[104]

Table 6 Levels of thromboxanes on lung cancer models

Factor	Models	Levels	Ref.
Thromboxane A2	NCI-H23, NCI-H460, and A549 cell lines	High	[100]
Thromboxane B2	A549 cell line	High	[105]
	NSCLC tissue	High	[106]
	NSCLC patient	High	[107]

NSCLC: Non-small cell lung cancer.

Table 7 Effects of endothelins on lung cancer models

Factor	Models	Effects	Ref.
Endothelin-1	A549 cell line	Proliferative and invasive	[108]
	SPC-A1 cell line	Proliferative	[109]
Endothelin-2	A549 cell line	Anti-apoptotic	[110]

Table 8 Levels of endothelins on lung cancer models

Factor	Models	Levels	Ref.
Endothelin-1	NSCLC tissue	High	[111]
	COR-L88 and A549 cell lines	High	[112]
	NSCLC patient	High	[113]
	NSCLC patient	High	[114]
Endothelin-2	LUAD tissue	High	[110]

LUAD: Lung adenocarcinoma; NSCLC: Non-small cell lung cancer.