Morbihan disease misdiagnosed as senile blepharoptosis and successfully treated with short-term minocycline and ketotifen: A case report

Table 1 Use of minocycline and its effects in Morbihan disease

Sex/age (yr)	Clinical features	Mast cell	Dose	Course	Effect
M/51[10]	Erythema and edema on left upper eyelid with complete left ptosis	-	N/A	N/A	Ineffective
M/70[6]	Erythematous edema on forehead, nose and periorbital areas	-	200 mg/d, 300 mg/d	Over 2 mo	Ineffective
M/54[12]	Erythema and edema on cheek and periorbital area	-	N/A	6 to 7 mo	Ineffective
M/30[13]	Edema on bilateral eyelids	-	100 mg/d, 50 mg/d	7 mo	Discontinued due to insignificant improvement and abnormal liver enzyme levels
M/74[7]	Swelling on right cheek and left upper eyelid	+	50 mg/d, 100 mg/d	4 mo	Partially effective
F/64[15]	Swelling on entire face	+	100 mg/d	6 mo	Significantly effective
M/38[18]	Periorbital indurated edema	+	N/A	3 mo	Ineffective
M/56[8]	Swelling on both eyelids and cheeks	+	100 mg/d	7 mo	Effective but discontinued due to abnormal liver enzyme levels
F/41[4]	Erythematous edema on upper eyelids, forehead, nose and cheeks	+	N/A	N/A	Effective
F/40[11]	Bilateral periorbital edema and intermittent blurry vision	-	N/A	A short period	Discontinued due to urticaria
N/A/88[1]	Swelling on left eyelid	N/A	N/A	N/A	Partially improved
M/28[14]	Edema and erythema on periorbital region, nose and cheeks; telangiectasias and pustules	-	100 mg/d	Over 2 mo	Partially improved

F: Female; M: Male; N/A: Not applicable.