Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2023; 11(19): 4692-4697
Published online Jul 6, 2023. doi: 10.12998/wjcc.v11.i19.4692
Published online Jul 6, 2023. doi: 10.12998/wjcc.v11.i19.4692
Morbihan disease misdiagnosed as senile blepharoptosis and successfully treated with short-term minocycline and ketotifen: A case report
Jun Na, Yan Wu, Department of Dermatology, Peking University First Hospital, Beijing 100034, China
Author contributions: Jun Na contributed to manuscript writing and editing, and data collection; Yan Wu contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Wu, MD, Chief Physician, Department of Dermatology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
Received: March 13, 2023
Peer-review started: March 13, 2023
First decision: May 19, 2023
Revised: May 31, 2023
Accepted: June 14, 2023
Article in press: June 14, 2023
Published online: July 6, 2023
Processing time: 108 Days and 23.3 Hours
Peer-review started: March 13, 2023
First decision: May 19, 2023
Revised: May 31, 2023
Accepted: June 14, 2023
Article in press: June 14, 2023
Published online: July 6, 2023
Processing time: 108 Days and 23.3 Hours
Core Tip
Core Tip: Morbihan disease is a rare skin disease that is mainly characterized by nonpitting erythematous edema on the upper two-thirds of the face. We report an atypical case of progressive blepharoptosis without obvious edema, as a reminder of the existence of this uncommon condition to dermatologists, neurologists, and ophthalmologists to reduce chances of misdiagnosis. Usually long-term minocycline is used to treat Morbihan disease but has uncertain efficacy. We successfully treated our patient with a combination of minocycline and ketotifen. We also summarized previous reports on the use of minocycline in Morbihan disease and noted that mast cells might be key histological predictors of the treatment response to minocycline.