Rare neonatal malignant primary orbital tumors: Three case reports

Figure 1 A 1-mo-old male newborn. A: A mass located in the right eye, with proptosis; B and C: Axial T-1 weighted (B) and T-2 weighted (C) magnetic resonance images of the orbit revealed a large mass near the lateral orbital wall with slightly shorter T1 and shorter T2 signals. The eyeball structure is unclear, with abnormal signals; D: Gross morphology of the tumor showing the tumor tissue around the eyeball; E and F: Histopathologic analysis including micrographs after hematoxylin-eosin (E, × 20; F, × 40). A small, round, dark blue tumor with a monotonous, highly cellular pattern was observed with tumor cell atypia, and poorly differentiated cells.

Figure 2 A 2-mo-old male patient. A: The right eye showed proptosis, which then increased gradually; B and C: Axial T-2 weighted (B) and coronal T-2 weighted (C) magnetic resonance images of the orbit revealing a large mass near the inner orbital wall with slightly long T2 signals. The mass compressed the optic nerve; D: Gross morphology of the tumor showing the tumor tissue invading the extraocular muscles; E and F: Histopathologic analysis including micrographs after hematoxylin-eosin (E, × 20; F, × 40) showing fibroblastic spindle cells with mild nuclear pleomorphism and a generous collagenous component.

Figure 3 A 5-mo-old female patient. A: Her right eye showed proptosis at birth, which increased gradually; B and C: Coronal T-2 weighted (B) and Axial T-2 weighted (C) magnetic resonance images of the orbit revealed a large mass near the lateral orbital wall with long T2 signals. The mass compressed the optic nerve; D: Gross morphology of the tumor indicated an off-white irregular tissue mass; E and F: Histopathologic analysis including micrographs after hematoxylin-eosin (E, × 20; F, × 40) showing a skeletal muscle scattered mass composed of elongated to spindle cells.