Zhang Y, Li YY, Yu HY, Xie XL, Zhang HM, He F, Li HY. Rare neonatal malignant primary orbital tumors: Three case reports. World J Clin Cases 2021; 9(26): 7825-7832 [PMID: 34621833 DOI: 10.12998/wjcc.v9.i26.7825]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 16, 2021; 9(26): 7825-7832 Published online Sep 16, 2021. doi: 10.12998/wjcc.v9.i26.7825
Rare neonatal malignant primary orbital tumors: Three case reports
Yan Zhang, Yue-Yue Li, Han-Yang Yu, Xiao-Li Xie, Hui-Min Zhang, Fang He, Hong-Yang Li
Yan Zhang, Han-Yang Yu, Hui-Min Zhang, Department of Ophthalmology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China
Yue-Yue Li, Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing 100039, China
Xiao-Li Xie, Department of Pathology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China
Fang He, Department of Ophthalmology, The Eighth Medical Center of PLA General Hospital, Beijing 100842, China
Hong-Yang Li, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Zhang Y contributed conceptualization; He F contributed data curation; Li YY contributed formal analysis; Zhang Y contributed funding acquisition; Yu HY contributed project administration; Xie XL contributed resources; Zhang HM contributed supervision; Zhang Y wrote the original draft; Li HY reviewed and edited the manuscript; all authors read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Received: February 24, 2021 Peer-review started: February 24, 2021 First decision: April 13, 2021 Revised: April 20, 2021 Accepted: July 6, 2021 Article in press: July 6, 2021 Published online: September 16, 2021 Processing time: 197 Days and 20.3 Hours
Abstract
BACKGROUND
Aggressive malignant primary orbital tumors are extremely rare in newborns. The current cases further clarify the clinical features of malignant primary orbital tumors in neonates.
CASE SUMMARY
At the time of presentation at the Seventh Center of People’s Liberation Army General (PLAG) Hospital, the children were 1-, 2- and 5-mo-old, respectively, and included 2 boys and 1 girl. All three cases had unilateral proptosis at birth, and underwent mass excision and histopathologic examination. A peripheral primary neuroectodermal tumor, an aggressive infantile fibromatosis and an embryonic rhabdomyosarcoma were diagnosed, respectively. The first case underwent routine chemotherapy following surgery but died within three months due to worsening condition as the tumor spread throughout the body. The other two children were treated by surgery, and at the follow-up visits 6 mo and 1 year after surgery, respectively, the wound was completed healed, and they had normal growth and development without radiotherapy or chemotherapy. A review of highly uncommon orbital tumors in newborns is also provided.
CONCLUSION
Malignant primary tumors should be considered in the presence of unilateral proptosis in newborns.
Core Tip: The first case underwent routine chemotherapy following surgery but died within three months due to worsening condition as the tumor spread throughout the body. The other two children were treated by surgery, and at the follow-up visits 6 mo and 1 year after surgery, respectively, the wound was completed healed, and they had normal growth and development without radiotherapy or chemotherapy.
