Early intervention in anxiety disorder patients with clinical high-risk factors for bipolar disorder: A randomized controlled trial

Figure 1 Flow of participants through the stages of the randomized controlled trial. This Consolidated Standards of Reporting Trials flow diagram illustrates the enrollment, randomization, allocation, follow-up, and analysis stages of the study.

Figure 2 Change in Hamilton Anxiety Rating Scale 14 scores over the 12-week trial. Data points represent the estimated mean change from baseline in Hamilton Anxiety Rating Scale 14 scores for the sertraline + lithium combination group (group B) and the sertraline monotherapy group (group A), based on the intention-to-treat population. Error bars represent 95% confidence intervals. ^aP < 0.05. HAMA: Hamilton Anxiety Rating Scale.

Figure 3 Change in Hamilton Depression Rating Scale 17 scores over the 12-week trial. Data points represent the estimated mean change from baseline in Hamilton Depression Rating Scale 17 scores for both treatment groups, based on the intention-to-treat population. Error bars represent 95% confidence intervals. ^aP < 0.05. HAMD: Hamilton Depression Rating Scale.