Zhong TT, Wang G, Wang XQ, Kong WD, Li XY, Xue Q, Zou YA. Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients. World J Clin Cases 2021; 9(30): 9070-9076 [PMID: 34786389 DOI: 10.12998/wjcc.v9.i30.9070]
Corresponding Author of This Article
Qian Xue, MSc, Chief Physician, Department of Neurology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. xueqian6199@163.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhong TT, Wang G, Wang XQ, Kong WD, Li XY, Xue Q, Zou YA. Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients. World J Clin Cases 2021; 9(30): 9070-9076 [PMID: 34786389 DOI: 10.12998/wjcc.v9.i30.9070]
World J Clin Cases. Oct 26, 2021; 9(30): 9070-9076 Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9070
Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients
Ting-Ting Zhong, Gang Wang, Xiao-Qin Wang, Wei-Dan Kong, Xiao-Yu Li, Qian Xue, Yu-An Zou
Ting-Ting Zhong, Gang Wang, Xiao-Qin Wang, Wei-Dan Kong, Xiao-Yu Li, Qian Xue, Yu-An Zou, Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Zhong TT designed and managed the study; Wang G, Wang XQ, Kong WD, LI XY and Zou YA collected and analyzed the data; Zhong TT, Wang G, Wang XQ, Kong WD, LI XY, Xue Q and Zou YA wrote the manuscript; Xue Q reviewed the manuscript; All authors approved the final version of the manuscript.
Supported byScientific Research Fund of Hebei Health Commission, No. 20210197.
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Hebei North University Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Qian Xue, MSc, Chief Physician, Department of Neurology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. xueqian6199@163.com
Received: June 30, 2021 Peer-review started: June 30, 2021 First decision: July 26, 2021 Revised: August 9, 2021 Accepted: August 16, 2021 Article in press: August 16, 2021 Published online: October 26, 2021 Processing time: 112 Days and 23.2 Hours
Core Tip
Core Tip: To better understand the pathogenesis of hemorrhagic transformation (HT) may help to avoid clinically relevant brain hemorrhages in patients with acute cerebral infarction treated with intravenous thrombolysis (IVT). The present study assessed the relationship between factors, including serum calcium, albumin, globulin and matrix metalloproteinase-9 levels (MMP-9), and the occurrence of HT following IVT in patients with acute cerebral infarction by comparing clinical and laboratory features between the HT and non-HT groups. National Institutes of Health stroke scale score, serum calcium, albumin, globulins and MMP-9 were independent factors influencing occurrence of HT in patients with cerebral infarction treated with IVT-recombinant tissue plasminogen activator.
