Zhong TT, Wang G, Wang XQ, Kong WD, Li XY, Xue Q, Zou YA. Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients. World J Clin Cases 2021; 9(30): 9070-9076 [PMID: 34786389 DOI: 10.12998/wjcc.v9.i30.9070]
Corresponding Author of This Article
Qian Xue, MSc, Chief Physician, Department of Neurology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. xueqian6199@163.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Observational Study
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Zhong TT, Wang G, Wang XQ, Kong WD, Li XY, Xue Q, Zou YA. Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients. World J Clin Cases 2021; 9(30): 9070-9076 [PMID: 34786389 DOI: 10.12998/wjcc.v9.i30.9070]
World J Clin Cases. Oct 26, 2021; 9(30): 9070-9076 Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9070
Serum calcium, albumin, globulin and matrix metalloproteinase-9 levels in acute cerebral infarction patients
Ting-Ting Zhong, Gang Wang, Xiao-Qin Wang, Wei-Dan Kong, Xiao-Yu Li, Qian Xue, Yu-An Zou
Ting-Ting Zhong, Gang Wang, Xiao-Qin Wang, Wei-Dan Kong, Xiao-Yu Li, Qian Xue, Yu-An Zou, Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Zhong TT designed and managed the study; Wang G, Wang XQ, Kong WD, LI XY and Zou YA collected and analyzed the data; Zhong TT, Wang G, Wang XQ, Kong WD, LI XY, Xue Q and Zou YA wrote the manuscript; Xue Q reviewed the manuscript; All authors approved the final version of the manuscript.
Supported byScientific Research Fund of Hebei Health Commission, No. 20210197.
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Hebei North University Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Qian Xue, MSc, Chief Physician, Department of Neurology, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. xueqian6199@163.com
Received: June 30, 2021 Peer-review started: June 30, 2021 First decision: July 26, 2021 Revised: August 9, 2021 Accepted: August 16, 2021 Article in press: August 16, 2021 Published online: October 26, 2021 Processing time: 112 Days and 23.2 Hours
ARTICLE HIGHLIGHTS
Research background
Intracranial hemorrhage is common after intravenous thrombolysis (IVT) in acute ischemic stroke. Increasing studies have focused on risk and predictive factors for hemorrhagic transformation (HT).
Research motivation
To understand the pathogenesis of HT and provide interventions that may help to increase the safety of IVT.
Research objectives
This study aimed to investigate the relationship of serum calcium, albumin, globulin and matrix metalloproteinase-9 (MMP-9) levels and HT after IVT.
Research methods
The study investigated patients receiving recombinant tissue plasminogen activator (rt-PA) for acute cerebral infarction. Demographic, clinical and laboratory information, HT and functional outcomes were compared between patients with HT and those without HT.
Research results
The study demonstrates that serum calcium and albumin levels were decreased in the HT group compared with the non-HT group and globulin and MMP-9 levels were increased in the HT group. This indicates that the low serum calcium and albumin levels and high globulin and MMP-9 levels are associated with the occurrence of HT following IVT in patients with cerebral infarction.
Research conclusions
National Institutes of Health stroke scale score, serum calcium, albumin, globulins and MMP-9 were independent factors influencing the occurrence of HT in patients with cerebral infarction treated with IVT-rt-PA.
Research perspectives
Further studies investigating additional potential factors are needed to confirm these results in patients treated with IVT-rt-PA to decrease the occurrence HT after IV rt-PA.
