Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2021; 9(28): 8453-8460
Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8453
Atypical granular cell tumor of the urinary bladder: A case report
Ming-Ze Wei, Ze-Jun Yan, Jun-Hui Jiang, Xiao-Long Jia
Ming-Ze Wei, Ze-Jun Yan, Jun-Hui Jiang, Xiao-Long Jia, Department of Urology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315000, Zhejiang Province, China
Author contributions: Wei MZ designed and drafted the article, and final approval of the version submitted; Yan ZJ was responsible for data acquisition, article drafting, and final approval of the version submitted; Jiang JH was responsible for data acquisition, critical revision of the article, and final approval of the version submitted; Jia XL was responsible for critical revision of the article, and final approval of the version submitted.
Informed consent statement: This case report was approved by the institutional ethical committee in our hospital, and written informed consent was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Long Jia, MA, MD, Surgeon, Department of Urology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, No. 59 Liuting Avenue, Ningbo 315000, Zhejiang Province, China. freshaaron@hotmail.com
Received: March 19, 2021
Peer-review started: March 19, 2021
First decision: April 29, 2021
Revised: May 14, 2021
Accepted: July 7, 2021
Article in press: July 7, 2021
Published online: October 6, 2021
Processing time: 192 Days and 20 Hours
Core Tip

Core Tip: ATP6AP1, ATP6AP2, BRD7 and GFRA2 gene mutations can potentially induce the progression of urinary bladder granular cell tumor. Characteristic biomarkers such as S-100, SOX10, CD56, pancytokeratin and HBM45 are essential for the diagnosis and differential diagnosis. Partial cystectomy is the treatment of choice to minimize recurrence and improve disease-free survival in benign cases. A relatively conservative transurethral resection of the bladder tumor can also be an alternative option according to the location of the primary tumor or at the patient's request. For malignant bladder granular cell tumors, radical surgical intervention with pelvic lymph node dissection is necessary.