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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2020; 8(20): 4966-4974
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4966
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4966
Multisystem involvement Langerhans cell histiocytosis in an adult: A case report
Bei-Bei Wang, Jun-Ru Ye, Yun-Lei Li, Yu-Ping Li, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Yi Jin, Jian-Min Li, Pathology Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Zhong-Wei Chen, Radiology Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Wang BB and Ye JR reviewed the literature and contributed to manuscript drafting; Li YL, Jin Y, Chen ZW and Li JM performed data curation, formal analysis; Li YP designed the research and performed supervision.
Informed consent statement: The patient involved in this case report provided written informed consent to the publication of case details and the accompanying images. And the written consent is available for review by the editor of this journal.
Conflict-of-interest statement: None.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yu-Ping Li, MD, Professor, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, South Baixiang, Ouhai District, Wenzhou 325000, Zhejiang Province, China. wzliyp@163.com
Received: May 5, 2020
Peer-review started: May 5, 2020
First decision: May 15, 2020
Revised: May 26, 2020
Accepted: August 26, 2020
Article in press: August 26, 2020
Published online: October 26, 2020
Processing time: 172 Days and 19.2 Hours
Peer-review started: May 5, 2020
First decision: May 15, 2020
Revised: May 26, 2020
Accepted: August 26, 2020
Article in press: August 26, 2020
Published online: October 26, 2020
Processing time: 172 Days and 19.2 Hours
Core Tip
Core Tip: Herein we describe the case of a young woman suffering from Langerhans cell histiocytosis (LCH) that affected organs including the lungs, liver, rib, pituitary gland, bilateral parotid gland, and bilateral submandibular glands. There have been very few previous reports of LCH with parotid gland and submandibular gland involvement. LCH is under- or misdiagnosed as a consequence of its variable and nonspecific presentation. Such misdiagnosis was evident in the patient described herein, and there was an extended period of time between initial symptom presentation and LCH diagnosis. This is a typical case of multi-system involvement LCH, and through this report we hope to help raise awareness of early LCH.