©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2019; 7(24): 4172-4185
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4172
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4172
Polyunsaturated fatty acids and DNA methylation in colorectal cancer
Mostafa Moradi Sarabi, Reza Mohammadrezaei Khorramabadi, Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad 381251698, Iran
Zohre Zare, Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad 381251698, Iran
Ebrahim Eftekhar, Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas 7919915519, Iran
Author contributions: Eftekhar E and Moradi Sarabi M supervised the work and wrote the manuscript; Mohammadrezaei Khorramabadi R and Zare Z collected the data, revised the literature, drew the figures and contributed to conception and design of the study; All authors contributed to critical revision, editing and final approval of the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interest related to this article.
Corresponding author: Ebrahim Eftekhar, PhD, Associate Professor, Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Jomhori Street, Bandar Abbas 7919915519, Iran. eftekhar19@gmail.com
Received: September 18, 2019
Peer-review started: September 18, 2019
First decision: October 14, 2019
Revised: November 27, 2019
Accepted: December 13, 2019
Article in press: December 13, 2019
Published online: December 26, 2019
Processing time: 97 Days and 19.1 Hours
Peer-review started: September 18, 2019
First decision: October 14, 2019
Revised: November 27, 2019
Accepted: December 13, 2019
Article in press: December 13, 2019
Published online: December 26, 2019
Processing time: 97 Days and 19.1 Hours
Core Tip
Core tip: Polyunsaturated fatty acids, including ω-3 (eicosapentaenoic acid and docosahexaenoic acid) may have a potential preventive role in colorectal cancer (CRC) by changing DNA methylation. In this review after summarizing the latest knowledge regarding changes in the DNA methylation pattern and its association with CRC, we aim to highlight the link between polyunsaturated fatty acids and DNA methylation in CRC, which is currently an interesting field of research.