Randomized Controlled Trial
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2019; 7(20): 3237-3246
Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3237
Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial
Xue-Ting Li, Chao-Qun Ma, Si-Hua Qi, Li-Min Zhang
Xue-Ting Li, Si-Hua Qi, Li-Min Zhang, Department of Anaesthesiology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Chao-Qun Ma, Department of Neurosurgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China
Author contributions: Li XT, Ma CQ, Qi SH, and Zhang LM designed the research; Li XT, Qi SH, and Zhang LM performed the research; Ma CQ and Zhang LM analyzed the data; and Zhang LM wrote the paper.
Institutional review board statement: The study was reviewed and approved by The Fourth Affiliated Hospital of Harbin Medical University Institutional Review Board.
Clinical trial registration statement: This study is registered at the Chinese Clinical Trial Register (http://www.chictr.org.cn). The registration identification number is No. ChiCTR1800017630.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Li-Min Zhang, MD, Adjunct Professor, Department of Anaesthesiology, The Fourth Affiliated Hospital, Harbin Medical University, 37 Yiyuan Street, Harbin 150001, Heilongjiang Province, China. university0501@163.com
Telephone: +86-451-82576626
Received: June 17, 2019
Peer-review started: June 17, 2019
First decision: August 3, 2019
Revised: September 3, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: October 26, 2019
Processing time: 131 Days and 13.2 Hours
Core Tip

Core tip: This study aimed to identify a comparatively satisfactory anesthetization regimen for painless gastroscopy and colonoscopy. The combination of propofol and dezocine can decrease propofol dosage, reduce the risk for the development of inhibitory effects on the cardiovascular and respiratory systems, increase analgesic effect, decrease body movement, shorten awakening time, and improve awakening quality. Anesthesia with propofol combined with dezocine is an adequate regimen of anesthesia and analgesia for gastroscopy and colonoscopy, which can increase the patient cooperation, quality and safety of the examination and treatment, and patient and physician satisfaction with anesthesia.