Li XT, Ma CQ, Qi SH, Zhang LM. Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial. World J Clin Cases 2019; 7(20): 3237-3246 [PMID: 31667174 DOI: 10.12998/wjcc.v7.i20.3237]
Corresponding Author of This Article
Li-Min Zhang, MD, Adjunct Professor, Department of Anaesthesiology, The Fourth Affiliated Hospital, Harbin Medical University, 37 Yiyuan Street, Harbin 150001, Heilongjiang Province, China. university0501@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Randomized Controlled Trial
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Li XT, Ma CQ, Qi SH, Zhang LM. Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial. World J Clin Cases 2019; 7(20): 3237-3246 [PMID: 31667174 DOI: 10.12998/wjcc.v7.i20.3237]
World J Clin Cases. Oct 26, 2019; 7(20): 3237-3246 Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3237
Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial
Xue-Ting Li, Chao-Qun Ma, Si-Hua Qi, Li-Min Zhang
Xue-Ting Li, Si-Hua Qi, Li-Min Zhang, Department of Anaesthesiology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Chao-Qun Ma, Department of Neurosurgery, Harbin 242 Hospital, Harbin 150066, Heilongjiang Province, China
Author contributions: Li XT, Ma CQ, Qi SH, and Zhang LM designed the research; Li XT, Qi SH, and Zhang LM performed the research; Ma CQ and Zhang LM analyzed the data; and Zhang LM wrote the paper.
Institutional review board statement: The study was reviewed and approved by The Fourth Affiliated Hospital of Harbin Medical University Institutional Review Board.
Clinical trial registration statement: This study is registered at the Chinese Clinical Trial Register (http://www.chictr.org.cn). The registration identification number is No. ChiCTR1800017630.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Corresponding author: Li-Min Zhang, MD, Adjunct Professor, Department of Anaesthesiology, The Fourth Affiliated Hospital, Harbin Medical University, 37 Yiyuan Street, Harbin 150001, Heilongjiang Province, China. university0501@163.com
Telephone: +86-451-82576626
Received: June 17, 2019 Peer-review started: June 17, 2019 First decision: August 3, 2019 Revised: September 3, 2019 Accepted: September 9, 2019 Article in press: September 9, 2019 Published online: October 26, 2019 Processing time: 131 Days and 13.2 Hours
ARTICLE HIGHLIGHTS
Research background
Endoscopy is usually associated with severe adverse reactions.
Research motivation
The optimal methods for inducing analgesia and sedation in endoscopy are areas of ongoing debate.
Research objectives
To evaluate the effects of propofol combined with dezocine, sufentanil, or fentanyl in painless gastroscopy and colonoscopy.
Research methods
Patients were randomly assigned to one of four groups for anesthesia: intravenous dezocine, sufentanil, fentanyl, or saline.
Research results
Propofol dosage, bispectral index, Steward score, awakening time, postoperative pain score, mean arterial pressure, pulse oxygen saturation, rates of hypopnea, jaw thrust, body movements, and usage of vasoactive drugs in the dezocine group were significantly better than those of the other three groups.
Research conclusions
The combination of propofol and dezocine can decrease propofol dosage, reduce the risk for the development of inhibitory effects on the respiratory and cardiovascular systems, increase analgesic effect, decrease body movement, shorten awakening time, and improve awakening quality.
Research perspectives
Anesthesia with propofol combined with dezocine is an adequate regimen of anesthesia and analgesia for gastroscopy and colonoscopy, which can increase the patient cooperation, quality and safety of the examination and treatment, and patient and physician satisfaction with anesthesia.
