Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2018; 6(6): 110-120
Published online Jun 16, 2018. doi: 10.12998/wjcc.v6.i6.110
Prognostic role of alpha-fetoprotein response after hepatocellular carcinoma resection
Narongsak Rungsakulkij, Wikran Suragul, Somkit Mingphruedhi, Pongsatorn Tangtawee, Paramin Muangkaew, Suraida Aeesoa
Narongsak Rungsakulkij, Wikran Suragul, Somkit Mingphruedhi, Pongsatorn Tangtawee, Paramin Muangkaew, Suraida Aeesoa, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Author contributions: Rungsakulkij N designed the study, collected and interpreted the data, and wrote the paper; Suragul W collected the data and wrote the paper; Mingphruedhi S collected and analyzed the data; Tangtawee P collected and analyzed the data; Muangkaew P collected the data; Aeesoa S analyzed the data.
Institutional review board statement: This study was reviewed and approved by the Ramathibodi Hospital Institutional Review Board Committee on Human Rights Related to Research Involving Human Subjects (protocol number ID 03-61-25).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creative commons.org/licenses/by-nc/4.0
Correspondence to: Wikran Suragul, FRCS (Gen Surg), MD, Doctor, Surgeon, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Praram VI Road, Ratchathewi, Bangkok 10400, Thailand. wikran.sur@mahidol.ac.th
Telephone: +66-2-2011527 Fax: +66-2-2012471
Received: April 26, 2018
Peer-review started: April 27, 2018
First decision: May 9, 2018
Revised: May 11, 2018
Accepted: May 30, 2018
Article in press: May 31, 2018
Published online: June 16, 2018
Processing time: 55 Days and 12.3 Hours
Core Tip

Core tip: Alpha-fetoprotein (AFP) is a widely used tumor marker for both pre- and post-treatment hepatocellular carcinoma (HCC) patients. To investigate whether changes in pre- and post-operation serum AFP levels were a predictive prognostic factor in HCC patients, we retrospectively analyzed 334 HCC patients who underwent hepatic resection at our hospital. Serum AFP responses were found to be a significant prognostic factor for surgical outcomes in patients with high pre-operative AFP levels. The non-response group, which was classified as having a < 50% decrease from preoperative AFP levels that were > 20 ng/mL, was associated with poor outcomes. In summary, post-surgery AFP levels are valuable for properly managing HCC patients.