©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Clin Cases. Mar 6, 2026; 14(7): 118719
Published online Mar 6, 2026. doi: 10.12998/wjcc.v14.i7.118719
Published online Mar 6, 2026. doi: 10.12998/wjcc.v14.i7.118719
Direct peritoneal resuscitation in sepsis and intra-abdominal infection: A scoping review
Marcelo Augusto Fontenelle Ribeiro Junior, Rafael Dib Possiedi, Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, United States
Marcelo Augusto Fontenelle Ribeiro Junior, Department of Surgery, Pontifical Catholic University of São Paulo-Campus Sorocaba, Sorocaba 18030070, São Paulo, Brazil
Rafael Dib Possiedi, Department of Surgery, Médecins Sans Frontières, Brussels 1050, Belgium
Rafael Dib Possiedi, Department of Surgery, United Kingdom-Medical, Manchester M3 3WD, United Kingdom
Leticia Stefani Pacheco, School of Medicine, Pontifical Catholic University of São Paulo-Campus Sorocaba, Sorocaba 18030070, São Paulo, Brazil
Nicolas de Cesaro Schpchacki, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Rio Grande do Sul, Brazil
Syeda Nafeesa Hashim, General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Makkah al Mukarramah, Saudi Arabia
Bruno Monteiro Tavares Pereira, Department of Surgery, University of Vassouras, Rio de Janeiro 27700-000, Rio de Janeiro, Brazil
Bruno Monteiro Tavares Pereira, Department of Surgery, Campinas Holly House General Surgery Residency Program, Campinas 13024-180, São Paulo, Brazil
Bruno Monteiro Tavares Pereira, Department of Surgery, Brazilian College of Digestive Surgery/Grupo Surgical Training Program, Campinas 13073-300, São Paulo, Brazil
Co-first authors: Marcelo Augusto Fontenelle Ribeiro Junior and Rafael Dib Possiedi.
Author contributions: Concepts, design and definition of intellectual content were provided by Ribeiro Junior MAF and Dib Possiedi R, served as the guarantor of the work, both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; literature research, data acquisition, data analysis, manuscript preparation, manuscript editing, review were performed by Ribeiro Junior MAF, Stefani Pacheco L, de Cesaro Schpchacki N, Nafeesa Hashim S, Monteiro Tavares Pereira B and Dib Possiedi R.
Conflict-of-interest statement: The authors declare no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Marcelo Augusto Fontenelle Ribeiro Junior, MD, PhD, FACS, Pro
Received: January 9, 2026
Revised: January 27, 2026
Accepted: February 10, 2026
Published online: March 6, 2026
Processing time: 55 Days and 10.7 Hours
Revised: January 27, 2026
Accepted: February 10, 2026
Published online: March 6, 2026
Processing time: 55 Days and 10.7 Hours
Core Tip
Core Tip: Direct peritoneal resuscitation has been proposed as an adjunctive strategy to address persistent visceral hypoperfusion, intestinal barrier injury, and dysregulated inflammation in sepsis. Although most human data derive from trauma populations, emerging experimental and limited clinical evidence suggest potential physiologic and abdominal benefits in selected septic patients, including improvements in metabolic parameters and facilitation of abdominal closure. However, current evidence remains limited and heterogeneous, and significant gaps must be addressed before wider clinical application in sepsis.