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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2026; 14(6): 118460
Published online Feb 26, 2026. doi: 10.12998/wjcc.v14.i6.118460
Published online Feb 26, 2026. doi: 10.12998/wjcc.v14.i6.118460
Low salivary thioredoxin-1 levels in periodontitis
Leonardo Lorente, Intensive Care Unit, Hospital Universitario de Canarias, La Laguna 38320, Spain
Esther Hernández Marrero, María José Marrero González, Carmen Hernández Marrero, Olga Hernández Marrero, Cándido Manuel Hernández Padilla, Department of Periodontal, Clínica Dental Cándido, La Laguna 38204, Spain
Pedro Abreu-Gonzalez, Department of Basic Medical Sciences, University of La Laguna, La Laguna 38320, Spain
Angel Daniel Lorente Martín, Department of Odontology, CEU San Pablo University, Madrid 28660, Spain
Marina Lorente Martín, Department of Nursing, Salus Infirmorum-Universidad Pontificia de Salamanca, Madrid 28015, Spain
Alejandro Jiménez, Research Unit, Hospital Universitario de Canarias, La Laguna 38320, Spain
Author contributions: Lorente L conceived, designed and coordinated the study, participated in acquisition and interpretation of data, and drafted the manuscript; Hernández Marrero E, Lorente Martín AD, Lorente Martín M, Marrero González MJ, Marrero CH, Hernández Marrero, and Hernández Padilla CM participated in acquisition of data; Abreu-Gonzalez P participated in salivary levels determinations; Jiménez A participated in the interpretation of data; all authors revised the manuscript critically for important intellectual content and made the final approval of the version to be published.
Institutional review board statement: This study was initiated after obtaining approval from the Clinical Research Ethics Committee of the Hospital Universitario de Canarias, No. CHUC_2023_138.
Informed consent statement: Prior to inclusion, all participants provided written informed consent.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: The datasets generated during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Leonardo Lorente, MD, PhD, Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, La Laguna 38320, Spain. lorentemartin@msn.com
Received: January 4, 2026
Revised: January 18, 2026
Accepted: January 26, 2026
Published online: February 26, 2026
Processing time: 42 Days and 7.9 Hours
Revised: January 18, 2026
Accepted: January 26, 2026
Published online: February 26, 2026
Processing time: 42 Days and 7.9 Hours
Core Tip
Core Tip: The protein thioredoxin-1 (TRX-1) has anti-oxidative effects and is involved in senescence, aging and different diseases. Salivary levels of TRX-1 in patients with periodontitis have not been explored. Novel findings of this study were the association of low salivary TRX-1 concentrations with periodontitis and its severity, and the capacity of salivary TRX-1 concentrations to help in the diagnosis of periodontitis.