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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2026; 14(6): 117269
Published online Feb 26, 2026. doi: 10.12998/wjcc.v14.i6.117269
Published online Feb 26, 2026. doi: 10.12998/wjcc.v14.i6.117269
Left ventricular mass in newborn with perinatal asphxia: Assessment of allometric relations and impact of birth weight
Josephat M Chinawa, Department of Pediatrics, College of Medicine, University of Nigeria Ituku/Ozalla, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu 400001, Nigeria
Okechukwu S Ani, Department of Pediatrics, ESUT Teaching Hospital, Enugu 400001, Nigeria
Odutola I Odetunde, Department of Pediatrics, University of Nigeria, Enugu 400001, Nigeria
Co-corresponding authors: Josephat M Chinawa and Okechukwu S Ani.
Author contributions: Chinawa JM, Ani OS, and Odutola IO conceptualized and designed the research; Chinawa JM, and Ani OS, screened patients and acquired clinical data; Chinawa JM and Ani OS, performed Data analysis; Chinawa JM, and Ani OS, wrote the paper. All the authors have read and approved the final manuscript. Chinawa JM and Ani OS, were responsible for patient screening, enrollment, collection of clinical data. Both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Both Chinawa JM and Ani OS have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Chinawa JM and Ani OS conceptualized, designed, and supervised the whole process of the project. Both authors searched the literature, revised and submitted the early version of the manuscript. Chinawa JM and Ani OS were instrumental and responsible for data re-analysis and re-interpretation, figure plotting, comprehensive literature search, preparation and submission of the current version of the manuscript. This collaboration between Chinawa JM and Ani OS is crucial for the publication of this manuscript and other manuscripts still in preparation.
Institutional review board statement: This was obtained from the Ethics and Research Committee of the Enugu State University Teaching Hospital, Enugu before the commencement of the study. The code number for the ethical clearance is ESUTHP/C-MAC/RA/034/201.
Informed consent statement: Informed written consent was obtained from the parent and/or legal guardian for study participation. In addition, an informed written consent was also obtained from the parents/caregivers of the newborn babies with birth asphyxia.
Conflict-of-interest statement: All authors declare that they have no competing interests.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: Data will be freely shared based on demand by the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Josephat M Chinawa, PhD, FACC, Professor, Department of Pediatrics, College of Medicine, University of Nigeria Ituku/Ozalla, University of Nigeria Teaching Hospital Ituku/Ozalla, 10 Thinkers Estate Enugu, Enugu 400001, Nigeria.
Received: December 3, 2025
Revised: December 19, 2025
Accepted: February 3, 2026
Published online: February 26, 2026
Processing time: 72 Days and 8.7 Hours
Revised: December 19, 2025
Accepted: February 3, 2026
Published online: February 26, 2026
Processing time: 72 Days and 8.7 Hours
Core Tip
Core Tip: Perinatal asphyxia may cause possible insults from hypoxic ischaemic damage to the myocardium especially of the left ventricle. This changes may affect left ventricular contractility. Hypoxic- ischemic- damage of the cardiac muscles may also cause increase in peripheral vascular resistance, leading to blood flow compromise to the left ventricle.