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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2026; 14(3): 117076
Published online Jan 26, 2026. doi: 10.12998/wjcc.v14.i3.117076
Published online Jan 26, 2026. doi: 10.12998/wjcc.v14.i3.117076
Diagnostic perspectives on mixed connective tissue disease with tuberculosis overlap
Shree V Dhotre, Department of Microbiology, Ashwini Rural Medical College, Hospital and Research Centre, Solapur 413006, Maharashtra, India
Pradnya S Dhotre, Department of Biochemistry, Ashwini Rural Medical College, Hospital and Research Centre, Solapur 413006, Maharashtra, India
Ajay M Gavkare, Department of Physiology, Government Medical College, Buldhana 443001, Maharashtra, India
Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India
Co-first authors: Shree V Dhotre and Pradnya S Dhotre.
Author contributions: Dhotre SV conceptualized and designed the study, developed the study outline, and coordinated manuscript preparation; Dhotre SV, Dhotre PS, and Nagoba BS made substantial contributions to the study design, data interpretation, and critical discussion of the manuscript; Dhotre SV and Nagoba BS drafted, critically revised, and edited the manuscript for important intellectual content and contributed to the literature review; all authors approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Basavraj S Nagoba, PhD, Assistant Dean, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India.
Received: November 28, 2025
Revised: December 29, 2025
Accepted: January 14, 2026
Published online: January 26, 2026
Processing time: 56 Days and 0.9 Hours
Revised: December 29, 2025
Accepted: January 14, 2026
Published online: January 26, 2026
Processing time: 56 Days and 0.9 Hours
Core Tip
Core Tip: This letter highlights practical diagnostic insights beyond the original case, including clinical red flags that should prompt reconsideration of a tuberculosis-only diagnosis, the value of early autoimmune serology, and the importance of parallel diagnostic pathways in tuberculosis-endemic regions.