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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2026; 14(3): 116125
Published online Jan 26, 2026. doi: 10.12998/wjcc.v14.i3.116125
Published online Jan 26, 2026. doi: 10.12998/wjcc.v14.i3.116125
Primary splenic histiocytic sarcoma: A case report and review of literature
Zhi-Dong Jia, Department of Hepatobiliary Surgery, Guangzhou Overseas Chinese Hospital, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
Cheng-Yan Zhang, Department of Laboratory, Clifford Hospital, Guangzhou 511495, Guangdong Province, China
Sheng-Zhi Liang, Department of General Surgery, The Affiliated Shunde Hospital of Jinan University, Foshan 528000, Guangdong Province, China
Hai-Liang Li, Department of Colorectal and Anal Surgery, The First People’s Hospital of Zunyi, The Third Affiliated Hospital of Zunyi Medical University, Zunyi 563099, Guizhou Province, China
Co-first authors: Zhi-Dong Jia and Cheng-Yan Zhang.
Author contributions: Jia ZD and Zhang CY wrote the main manuscript, and they contributed equally to this manuscript and are co-first authors; Jia ZD and Li HL revised the final manuscript; Liang SZ assisted with information research, data collection, and icon creation. All authors have read and approved the final manuscript.
Supported by the Science and Technology Projects in Guangzhou, No. 202201010653; Guangdong Provincial Medical Science and Technology Research Fund, No. A2021200; and Jinan University Medical Collaborative Fund, No. MF220209.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Liang Li, MD, Director, Department of Colorectal and Anal Sur
Received: November 3, 2025
Revised: December 13, 2025
Accepted: January 6, 2026
Published online: January 26, 2026
Processing time: 80 Days and 15 Hours
Revised: December 13, 2025
Accepted: January 6, 2026
Published online: January 26, 2026
Processing time: 80 Days and 15 Hours
Core Tip
Core Tip: Splenic histiocytic sarcoma (HS) is a rare lymphohematopoietic malignancy with nonspecific clinical manifestations, diagnostic challenges, high aggressiveness, and a poor prognosis. A 67-year-old woman was found to have a large splenic mass during a routine physical examination 1 month before presentation. After multidisciplinary discussion, laparoscopic splenectomy was recommended. The pathological findings were most compatible with the diagnosis of HS. A 6-month postoperative telephonic follow-up revealed that the patient felt well. Despite the poor prognosis, HS remains treatable. Early and definitive diagnosis based on pathology is required to optimize treatment.