Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report

doi:10.12998/wjcc.120444

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Jul 26, 2026; 14(21): 120444
Published online Jul 26, 2026. doi: 10.12998/wjcc.120444

Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report

Karam Karam, Kim Charro, Dorra Kechaou, Wajed Abarah, Jacquot Rakotobe, Christophe Locher

Karam Karam, Kim Charro, Christophe Locher, Department of Gastroenterology and Hepatology, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France

Dorra Kechaou, Department of Anatomical Pathology, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France

Wajed Abarah, Department of Hematology and Oncology, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France

Jacquot Rakotobe, Department of Radiology and Medical Imaging, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France

Author contributions: Karam K, Charro K, Kechaou D, Abarah W, Rakotobe J, and Locher C conceptualized the study, curated experimental data and prepared the original manuscript draft; and all authors reviewed and approved the final submitted version of the manuscript.

AI contribution statement: We would like to affirm that our manuscript was not generated using an AI tool. The work reflects our own research, analysis, writing, and intellectual contributions.

Informed consent statement: A signed informed consent was obtained.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Karam Karam, Assistant Professor, Department of Gastroenterology and Hepatology, Grand Hopital de l’Est Franicilien, 6-8 Rue Saint-Fiacre, Meaux 77100, Ile-de-France, France. karamek7@gmail.com

Received: February 28, 2026
Revised: March 2, 2026
Accepted: July 1, 2026
Published online: July 26, 2026
Processing time: 144 Days and 22.1 Hours

Core Tip

Core Tip: This case highlights an important clinical message: Mantle cell lymphoma should be included in the differential diagnosis of rectal bleeding when endoscopic findings resemble ulcerative colitis or proctitis. Awareness of this rare presentation may facilitate earlier diagnosis and appropriate oncologic management. Given the rarity of gastrointestinal involvement, particularly at the rectal level, prospective studies are needed to better define optimal therapeutic strategies and improve clinical outcomes in this subset of patients.