Karam K, Charro K, Kechaou D, Abarah W, Rakotobe J, Locher C. Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report. World J Clin Cases 2026; 14(21): 120444 [DOI: 10.12998/wjcc.120444]
Corresponding Author of This Article
Karam Karam, Assistant Professor, Department of Gastroenterology and Hepatology, Grand Hopital de l’Est Franicilien, 6-8 Rue Saint-Fiacre, Meaux 77100, Ile-de-France, France. karamek7@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
case-report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2026; 14(21): 120444 Published online Jul 26, 2026. doi: 10.12998/wjcc.120444
Rectal mantle cell lymphoma endoscopically mimicking ulcerative proctitis: A case report
Karam Karam, Kim Charro, Dorra Kechaou, Wajed Abarah, Jacquot Rakotobe, Christophe Locher
Karam Karam, Kim Charro, Christophe Locher, Department of Gastroenterology and Hepatology, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France
Dorra Kechaou, Department of Anatomical Pathology, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France
Wajed Abarah, Department of Hematology and Oncology, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France
Jacquot Rakotobe, Department of Radiology and Medical Imaging, Grand Hopital de l’Est Franicilien, Meaux 77100, Ile-de-France, France
Author contributions: Karam K, Charro K, Kechaou D, Abarah W, Rakotobe J, and Locher C conceptualized the study, curated experimental data and prepared the original manuscript draft; and all authors reviewed and approved the final submitted version of the manuscript.
AI contribution statement: We would like to affirm that our manuscript was not generated using an AI tool. The work reflects our own research, analysis, writing, and intellectual contributions.
Informed consent statement: A signed informed consent was obtained.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Karam Karam, Assistant Professor, Department of Gastroenterology and Hepatology, Grand Hopital de l’Est Franicilien, 6-8 Rue Saint-Fiacre, Meaux 77100, Ile-de-France, France. karamek7@gmail.com
Received: February 28, 2026 Revised: March 2, 2026 Accepted: July 1, 2026 Published online: July 26, 2026 Processing time: 144 Days and 22.1 Hours
Abstract
BACKGROUND
Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma characterized by a chromosomal translocation between chromosomes 11 and 14, resulting in cyclin D1 overexpression. MCL frequently involves extranodal sites, including the bone marrow, spleen, liver, and gastrointestinal tract. However, rectal involvement is exceedingly rare and sparsely reported in the medical literature.
CASE SUMMARY
We report a case of rectal MCL initially misdiagnosed as ulcerative proctitis based on endoscopic findings, highlighting the importance of histopathological evaluation in atypical presentations of proctitis.
CONCLUSION
This case highlights an important clinical message: MCL should be included in the differential diagnosis of rectal bleeding when endoscopic findings resemble ulcerative colitis or proctitis. Awareness of this rare presentation may facilitate earlier diagnosis and appropriate oncologic management.
Core Tip: This case highlights an important clinical message: Mantle cell lymphoma should be included in the differential diagnosis of rectal bleeding when endoscopic findings resemble ulcerative colitis or proctitis. Awareness of this rare presentation may facilitate earlier diagnosis and appropriate oncologic management. Given the rarity of gastrointestinal involvement, particularly at the rectal level, prospective studies are needed to better define optimal therapeutic strategies and improve clinical outcomes in this subset of patients.
