Long-term survival in patients with primary malignant brain tumors after postoperative home hydrogen inhalation: Three case reports

doi:10.12998/wjcc.121466

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Jul 16, 2026; 14(20): 121466
Published online Jul 16, 2026. doi: 10.12998/wjcc.121466

Long-term survival in patients with primary malignant brain tumors after postoperative home hydrogen inhalation: Three case reports

Nikolai N Korpan, Ding-Gang Li, Bing Liang, Wei Qian, Xiao-Feng Kong, Ke-Cheng Xu

Ke-Cheng Xu, Wei Qian, Department of Oncology, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China

Xiao-Feng Kong, Institute of Hydrogen Medicine, Institute of Biomedical Translational Research, Jinan University, Guangzhou 510308, Guangdong Province, China

Bing Liang, Ding-Gang Li, International Center of Oncology, Royal Lee Cancer Hospital, Guangzhou 511065, Guangdong Province, China

Nikolai N Korpan, International Institute of Cryosurgery, Vienna 1190, Austria

Nikolai N Korpan, Department of General Surgery, Bogomolets National Medical University, Kyiv 01601, Ukraine

Author contributions: Xu KC and Korpan NN provided the idea for the present study and evaluated the results of real-world evidence, and revised the manuscript; Kong XF, Qian W, and Liang B collected case data and drafted the initial manuscript; Li DG reviewed the manuscript. All authors have read and approved the final manuscript submitted and agree to be accountable for all aspects of the work presented therein.

Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Nikolai N Korpan, MD, PhD, Professor, International Institute of Cryosurgery, Billrothstraße 78, Vienna 1190, Austria. nikolai.korpan@cryosurgery.at

Received: March 27, 2026
Revised: April 13, 2026
Accepted: June 15, 2026
Published online: July 16, 2026
Processing time: 106 Days and 14.5 Hours

Core Tip

Core Tip: We report three cases of high-grade brain tumors following standard conventional therapy combined with long-term home-based hydrogen inhalation. All patients achieved stable disease and favorable functional recovery. Their overall survival was markedly prolonged, exceeding the standard prognostic expectations. This simple and safe intervention warrants further clinical investigation.