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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 16, 2026; 14(2): 110627
Published online Jan 16, 2026. doi: 10.12998/wjcc.v14.i2.110627
Published online Jan 16, 2026. doi: 10.12998/wjcc.v14.i2.110627
Functional and aesthetic oral rehabilitation after cancer treatment using dental prosthesis and hyaluronic acid injections: A case report and review of literature
Nadège Hessloehl, Pierre-Yves Collart-Dutilleul, Olivier Romieu, Delphine Carayon, Department of Odontology, Centre Hospitalier Universitaire de Montpellier, Montpellier 34000, Occitanie, France
Pierre-Yves Collart-Dutilleul, Olivier Romieu, Delphine Carayon, Laboratory Bioengineering and Nanosciences, University of Montpellier, Montpellier 34000, Occitanie, France
Co-first authors: Nadège Hessloehl and Pierre-Yves Collart-Dutilleul.
Author contributions: Hessloehl N and Collart-Dutilleul P contributed equally to this manuscript and are co-first authors. Hessloehl N followed the patient during the whole process of rehabilitation, taking care of conservative dental treatments and prosthetic rehabilitation, and wrote the first draft of the manuscript; Collart-Dutilleul P, Romieu O, and Carayon D revised the manuscript; Collart-Dutilleul P made the hyaluronic acid injections, corrected and edited the manuscript; Romieu O supervised all the dental treatments; Carayon D supervised prosthetic rehabilitation, was the main responsible for patient care and follow-up.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pierre-Yves Collart-Dutilleul, PhD, DDS, Professor, Laboratory Bioengineering and Nanosciences, University of Montpellier, 545 Avenue du Professeur Jean-Louis Viala, Montpellier 34000, Occitanie, France.
Received: June 11, 2025
Revised: July 21, 2025
Accepted: December 22, 2025
Published online: January 16, 2026
Processing time: 219 Days and 16.7 Hours
Revised: July 21, 2025
Accepted: December 22, 2025
Published online: January 16, 2026
Processing time: 219 Days and 16.7 Hours
Core Tip
Core Tip: This case highlights the full oral rehabilitation of a patient who underwent segmental mandibulectomy with fibula free flap reconstruction for advanced oral squamous cell carcinoma. A multidisciplinary approach was employed to address trismus, masticatory dysfunction, and aesthetic deficits, combining custom-made dentures, fluoride trays, and hyaluronic acid injections. Hyaluronic acid contributed to improving facial symmetry and reducing scarring, enhancing the patient’s quality of life. This case underscores the importance of innovative, patient-centered dental interventions in managing complex post-surgical complications and demonstrates a practical, reproducible approach applicable to similar clinical scenarios.